ArticleEnvironmental health perspectives2021
A Roadmap to the Structure-Related Metabolism Pathways of Per- and Polyfluoroalkyl Substances in the Early Life Stages of Zebrafish (
Article in Environmental health perspectives, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed.
- PFAS Mixture Composition and Internal Exposure Profiles Shape Biological Responses under Field-Realistic Exposure.Environmental science & technology · 2026Article
- Article
- New Mechanistic Evidence for Perfluorodecanoic Acid (PFDA) Teratogenicity via CYP26A1-Mediated Retinoic Acid Metabolism and Signaling.Chemical research in toxicology · 2026Article
- Evaluations of Sex Differences in Dosimetry in Rats Following Perfluorohexanesulfonamide (PFHxSA) Oral Exposure.Toxics · 2025Article
- Models and challenges for studying forever chemicals and their impact on human health.Disease models & mechanisms · 2025Review
- Comparison of transcriptomic points of departure with apical endpoints in developing zebrafish exposed to PFOS, PFOA, or PFHxS.Toxicological sciences : an official journal of the Society of Toxicology · 2025Article
- Article
- Single-cell RNA sequencing reveals tissue-specific transcriptomic changes induced by perfluorooctanesulfonic acid (PFOS) in larval zebrafish (Danio rerio).Journal of hazardous materials · 2025Article
- Expanding PFAS Identification with Transformation Product Libraries: Nontargeted Analysis Reveals Biotransformation Products in Mice.Environmental science & technology · 2025Article
- Bioconcentration, maternal transfer, and toxicokinetics of PFOS in a multi-generational zebrafish exposure.Environmental toxicology and chemistry · 2025Article
- Per- and polyfluoroalkyl substances alter innate immune function: evidence and data gaps.Journal of immunotoxicology · 2024Review
- Considerations and challenges in support of science and communication of fish consumption advisories for per- and polyfluoroalkyl substances.Integrated environmental assessment and management · 2024Review
- Using Zebrafish to Screen Developmental Toxicity of Per- and Polyfluoroalkyl Substances (PFAS).Toxics · 2024Article
- Diverse PFAS produce unique transcriptomic changes linked to developmental toxicity in zebrafish.Frontiers in toxicology · 2024Article
- Survival, Growth, and Reproduction Responses in a Three-Generation Exposure of the Zebrafish (Danio rerio) to Perfluorooctane Sulfonate.Environmental toxicology and chemistry · 2024Article
- Differential Developmental Neurotoxicity and Tissue Uptake of the Per- and Polyfluoroalkyl Substance Alternatives, GenX and PFBS.Environmental science & technology · 2023Article
- Review of the zebrafish as a model to investigate per- and polyfluoroalkyl substance toxicity.Toxicological sciences : an official journal of the Society of Toxicology · 2023Review
- Tissue Bioconcentration Pattern and Biotransformation of Per-Fluorooctanoic Acid (PFOA) inFoods (Basel, Switzerland) · 2023Article
- Review
- Article
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThousands of per- and polyfluoroalkyl substances (PFAS) with diverse structures have been detected in the ambient environment. Apart from a few well-studied PFAS, the structure-related toxicokinetics of a broader set of PFAS remain unclear.
objectivesTo understand the toxicokinetics of PFAS, we attempted to characterize the metabolism pathways of 74 structurally diverse PFAS samples from the U.S. Environmental Protection Agency's PFAS screening library.
methodsUsing the early life stages of zebrafish (
resultsOur findings identified five structural categories of PFAS prone to metabolism. The metabolism pathways of PFAS were highly related to their structures as exemplified by fluorotelomer alcohols that the predominance of
conclusionsWe suggest that the roadmap of the structure-related metabolism pathways of PFAS established in this study would provide a starting point to inform the potential health risks of other PFAS. https://doi.org/10.1289/EHP7169.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.