ArticleApplied and environmental microbiology2021
Heat-Treated Virus Inactivation Rate Depends Strongly on Treatment Procedure: Illustration with SARS-CoV-2.
Article in Applied and environmental microbiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 1 synthesis or guideline pooled it, 34 citations in OpenAlex.
- Disinfection methods against SARS-CoV-2: a systematic review.The Journal of hospital infection · 2022Pooled it
- Tamm Plasmon Resonance Responsiveness to SARS-CoV-2 Virus-Like Particles.Nanophotonics (Berlin, Germany) · 2026Article
- Seasonal patterns of viromes in urban aquatic environments of Manitoba.Applied and environmental microbiology · 2025Article
- Red Sea Bream Iridovirus Stability in Freeze-Thaw Cycles: Quantitative Assays of Infectious Particles.Animals : an open access journal from MDPI · 2025Article
- Heat Treatment as a Safe-Handling Procedure for Rift Valley Fever Virus.Pathogens (Basel, Switzerland) · 2024Article
- Chemical and Heat Treatment for Viral Inactivation in Porcine-Derived Gelatin.BMC biotechnology · 2024Article
- Inactivation of Avian Influenza A(H5N1) Virus in Raw Milk at 63°C and 72°C.The New England journal of medicine · 2024Article
- Optimizing heat inactivation for SARS-CoV-2 at 95 °C and its implications: A standardized approach.Heliyon · 2024Article
- Host and viral determinants of airborne transmission of SARS-CoV-2 in the Syrian hamster.eLife · 2024Article
- Validating the inactivation of viral pathogens with a focus on SARS-CoV-2 to safely transfer samples from high-containment laboratories.Frontiers in cellular and infection microbiology · 2024Article
- Inactivated and Immunogenic SARS-CoV-2 for Safe Use in Immunoassays and as an Immunization Control for Non-Clinical Trials.Viruses · 2023Article
- Development of a charged model of the SARS-CoV-2 viral surface.Biochimica et biophysica acta. Biomembranes · 2023Article
- Investigation on the applicability of a long-range reverse-transcription quantitative polymerase chain reaction assay for the rapid detection of active viruses.BMC microbiology · 2022Article
- Testing of a mobile heating facility to sanitize N-95 respirators against an enveloped respiratory virus.International journal of circumpolar health · 2022Article
- Evaluation of Five Buffers for Inactivation of Monkeypox Virus and Feasibility of Virus Detection Using the Panther FusionViruses · 2022Article
- Flexible, disposable photocatalytic plastic films for the destruction of viruses.Journal of photochemistry and photobiology. B, Biology · 2022Article
- Heat inactivation of clinical COVID-19 samples on an industrial scale for low risk and efficient high-throughput qRT-PCR diagnostic testing.Scientific reports · 2022Article
- Liquid-Immersion Reprocessing Effects on Filtration Efficiency of 'Single-Use' Commercial Medical Face Masks.Annals of work exposures and health · 2022Article
- Review of air disinfection approaches and proposal for thermal inactivation of airborne viruses as a life-style and an instrument to fight pandemics.Applied thermal engineering · 2022Review
- Changes in Dietary Patterns and Clinical Health Outcomes in Different Countries during the SARS-CoV-2 Pandemic.Nutrients · 2021Review
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Decontamination helps limit environmental transmission of infectious agents. It is required for the safe reuse of contaminated medical, laboratory, and personal protective equipment, and for the safe handling of biological samples. Heat treatment is a common decontamination method, notably used for viruses. We show that for liquid specimens (here, solution of SARS-CoV-2 in cell culture medium), the virus inactivation rate under heat treatment at 70°C can vary by almost two orders of magnitude depending on the treatment procedure, from a half-life of 0.86 min (95% credible interval [CI] 0.09, 1.77) in closed vials in a heat block to 37.04 min (95% CI 12.64, 869.82) in uncovered plates in a dry oven. These findings suggest a critical role of evaporation in virus inactivation via dry heat. Placing samples in open or uncovered containers may dramatically reduce the speed and efficacy of heat treatment for virus inactivation. Given these findings, we reviewed the literature on temperature-dependent coronavirus stability and found that specimen container types, along with whether they are closed, covered, or uncovered, are rarely reported in the scientific literature. Heat-treatment procedures must be fully specified when reporting experimental studies to facilitate result interpretation and reproducibility, and must be carefully considered when developing decontamination guidelines.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.