Evidence map›Paper›PMID 34288597›Full record

ArticleCancer communications (London, England)2021

Harnessing the soil: reshaping the tumor microenvironment towards an antitumor immune state by low-dose metformin.

Yusheng Lin, Shuhong Wang, Edwin Bremer, Hao Zhang

Abstract readEditorial
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancer communications (London, England), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Metformin Alone and in Combinations Alter the Methylation Patterns ofEndocrine, metabolic & immune disorders drug targets · 2026
    Article
  2. Article
  3. Identification and characterization of FGFR2Journal of experimental & clinical cancer research : CR · 2022
    Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Yusheng LinInstitute of Precision Cancer Medicine and Pathology, Jinan University Medical College, Guangzhou, Guangdong, 510632, P. R. China.
Shuhong WangInstitute of Precision Cancer Medicine and Pathology, Jinan University Medical College, Guangzhou, Guangdong, 510632, P. R. China.
Edwin BremerDepartment of Hematology, University Medical Center Groningen, University of Groningen, Groningen 9700 RB, The Netherlands.
Hao ZhangInstitute of Precision Cancer Medicine and Pathology, Jinan University Medical College, Guangzhou, Guangdong, 510632, P. R. China.ORCID 0000-0002-2860-5912

Funding

Clinical Research Enhancement Initiative of Shantou University Medical College 201421Integration of Industry, Education and Research of Guangdong Province 2011A090100024National Natural Science Foundation of China 30973508National Natural Science Foundation of China 81071736National Natural Science Foundation of China 81572876National Natural Science Foundation of China 81773087National Natural Science Foundation of China 82072683Natural Science Foundation of Guangdong Province of China 2021A1515012522Natural Science Foundation of Guangdong Province of China 9151018004000000Science and Technology Planning Project of Guangdong Province of China 2019A030317024
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Antineoplastic AgentsMetforminNeoplasmsHumansSoilTumor MicroenvironmentAntineoplastic AgentsMetforminSoil

Identifiers

PMID34288597
PMCPMC8360638

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.