Evidence map›Paper›PMID 34288563›Full record

ArticleCancer medicine2021

Incidence trends of squamous cell carcinoma of the head and neck (SCCHN) in the aging population--A SEER-based analysis from 2000 to 2016.

Melissa A Taylor, Jeffery Switchenko, William Stokes, Mihir R Patel, Mark McDonald, Conor Steuer, Ashley Aiken, Jonathan J Beitler, Dong M Shin, Nabil F Saba

Open access · goldAbstract readHistorical Article
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancer medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
2.1field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 11 citations in OpenAlex.

  1. Pooled it
  2. Common white lesions of the oral cavity: Review of clinical presentations and management.Canadian family physician Medecin de famille canadien · 2025
    Review
  3. Biologics: The Good, the Bad and the Future of Ear, Nose and Throat.Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India · 2024
    Article
  4. Review
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Melissa A TaylorEmory University, School of Medicine, Atlanta, GA, USA.ORCID 0000-0002-2629-978X
Jeffery SwitchenkoDepartment of Biostatistics and Bioinformatics, Emory University, Atlanta, GA, USA.
William StokesEmory University, Winship Cancer Institute, Atlanta, GA, USA.
Mihir R PatelEmory University, Winship Cancer Institute, Atlanta, GA, USA.
Mark McDonaldEmory University, Winship Cancer Institute, Atlanta, GA, USA.
Conor SteuerEmory University, Winship Cancer Institute, Atlanta, GA, USA.
Ashley AikenEmory University, Winship Cancer Institute, Atlanta, GA, USA.
Jonathan J BeitlerEmory University, Winship Cancer Institute, Atlanta, GA, USA.ORCID 0000-0002-1519-2071
Dong M ShinEmory University, Winship Cancer Institute, Atlanta, GA, USA.
Nabil F SabaEmory University, Winship Cancer Institute, Atlanta, GA, USA.
Emory University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundTobacco and alcohol use are risk factors for Squamous Cell Carcinoma of the Head and Neck (SCCHN); however, there is growing recognition of HPV as a risk factor for SCCHN. HPV-related SCCHN is thought to affect mostly middle-aged individuals but as the US population ages, it is important to evaluate the change in incidence of HPV- and non-HPV-related SCCHN in individuals who are ≥65 years old.

methodsThis was a retrospective study using data from a population-based cancer registry (SEER) to identify individuals ≥65 years old diagnosed with SCCHN between 2000 and 2016 also stratified by sex, race, and birth cohort. The subgroups of HPV-associated and non-HPV associated sites were analyzed independently. The incidence per year was calculated and joinpoint detection was used to identity significant changes in incidence trends and annual percent change (APC).

resultsFor HPV-associated sites from 2000 to 2016, there was an average annual rate of 10.8 per 100,000 individuals with an APC of 2.92% (p = <0.05). For HPV- and non-HPV-related SCCHN males had a higher annual rate compared to females, 54.5 versus 18.0 in non-HPV-related and 19.1 versus 4.4 in HPV-related sites. For non-HPV-related sites there was a decrease in APC across all stratified groups. For HPV-related sites there was an increase in APC across all stratified groups, especially males (APC 8.82% 2006-2016 p < 0.05) and White individuals (APC 8.19% 2006-2016 p < 0.05). When stratified by birth cohort, HPV-related SCCHN sites had a higher APC in ages 65-69 (8.38% p < 0.05) and 70-74 (8.54% p < 0.05).

conclusionAmong the population ≥65 years old from 2000 to 2016, the incidence rate for HPV-related SCCHN sites has increased across all stratified groups, especially in White individuals, males, and age groups 65-74. The incidence rate for non-HPV-related sites has decreased across all stratified groups during this time.

Indexed as

AgedAged, 80 and overAgingFemaleHistory, 21st CenturyHumansIncidenceMaleSEER ProgramSquamous Cell Carcinoma of Head and Neckelderly populationHPVincidence trendssquamous cell carcinoma of the head and neck

Identifiers

PMID34288563
PMCPMC8419769
OpenAlexW3183898807

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.