Evidence map›Paper›PMID 34288520›Full record

ArticleCancer medicine2021

Clinical presentation and survival outcomes of well-differentiated thyroid cancer in Filipinos.

Uchechukwu C Megwalu, Yifei Ma, Nosayaba Osazuwa-Peters, Lisa A Orloff

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancer medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
1.5field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it, 13 citations in OpenAlex.

  1. Pooled it
  2. Long-Term Survival Rate for Moroccan Patients with Differentiated Thyroid Cancer.Asian Pacific journal of cancer prevention : APJCP · 2025
    Article
  3. Article
  4. Thyroid Cancer Survival in the Multiethnic Cohort Study.International journal of environmental research and public health · 2024
    Article
  5. Article
  6. Epidemiology of Thyroid Cancer.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2022
    Article
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Uchechukwu C MegwaluDepartment of Otolaryngology-Head and Neck Surgery, Stanford University School of Medicine, Stanford, California, USA.ORCID 0000-0001-5132-8864
Yifei MaDepartment of Otolaryngology-Head and Neck Surgery, Stanford University School of Medicine, Stanford, California, USA.
Nosayaba Osazuwa-PetersDepartment of Head and Neck Surgery and Communication Sciences, Duke University School of Medicine, Durham, North Carolina, USA.ORCID 0000-0002-1390-9753
Lisa A OrloffDepartment of Otolaryngology-Head and Neck Surgery, Stanford University School of Medicine, Stanford, California, USA.
Stanford University · USDuke University · US

Funding

NCCDPHP CDC HHS NU58DP006344NCI NIH HHS HHSN261201800009CNCI NIH HHS HHSN261201800009INCI NIH HHS HHSN261201800015CNCI NIH HHS HHSN261201800015INCI NIH HHS HHSN261201800032CNCI NIH HHS HHSN261201800032I
6 · The paper itself

Abstract

backgroundFilipinos have higher recurrence rates compared to other racial/ethnic groups, which might suggest a higher propensity for aggressive disease. The goal of this study was to perform a population-based analysis of disease extent at diagnosis and survival outcomes in Filipino patients with well-differentiated thyroid cancer relative to other racial/ethnic groups.

methodsThe study cohort comprised adult patients with well-differentiated thyroid cancer diagnosed between 2004 and 2015, identified in the California Cancer Registry. Rates of extrathyroidal extension, nodal metastasis, and distant metastasis were compared between Filipinos, Non-Filipino Asians, and Non-Asians using multilevel logistic regression models. Survival outcomes were compared using Cox regression models, utilizing a sequential modeling approach.

resultsFilipino ethnicity was associated with extrathyroidal extension (OR 1.35, 95% CI 1.11-1.63) compared with non-Asians and non-Filipino Asians. Filipino ethnicity was also associated with nodal metastasis (OR 1.32, 95% CI 1.18-1.46), and with worse OS (Hazard Ratio [HR] 1.45, 95% CI 1.20-1.75) and DSS (HR 1.51, 95% CI 1.12-2.04). After adjusting for demographic and clinical factors, Filipino ethnicity was no longer associated with OS (HR 1.03, 95% CI 0.84-1.25) or DSS (HR 0.93, 95% CI 0.68-1.28).

conclusionFilipino patients with thyroid cancer are more likely to present with locoregionally advanced disease compared with non-Filipino Asians and non-Asians. Furthermore, Filipino patients have worse survival outcomes compared with non-Filipino Asians and non-Asians. However, this appears to be driven by the higher rates of locoregionally advanced disease in Filipino patients.

Indexed as

AsianCell DifferentiationFemaleHumansIncidenceMaleSurvival AnalysisThyroid NeoplasmsTreatment OutcomeAsiansFilipinohealth status disparitiesminority healththyroid cancer

Identifiers

PMID34288520
PMCPMC8419748
OpenAlexW3183208340

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.