Evidence map›Paper›PMID 34288440›Full record

ReviewInternational journal of laboratory hematology2021

COVID-19-related laboratory coagulation findings.

Katrien M J Devreese

Open access · bronzeAbstract readReview
In one paragraph

Review in International journal of laboratory hematology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 1 pooled it
3.1field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 1 synthesis or guideline pooled it, 51 citations in OpenAlex.

  1. Pooled it
  2. Observational
  3. Article
  4. Observational
  5. Article
  6. Innovative Diagnostic Solutions in Hemostasis.Diagnostics (Basel, Switzerland) · 2024
    Review
  7. Review
  8. Coagulopathy during COVID-19 infection: a brief review.Clinical and experimental medicine · 2023
    Review
  9. Article
  10. Article
  11. Article
  12. Thromboprophylaxis in Pregnant Women with COVID-19: An Unsolved Issue.International journal of environmental research and public health · 2023
    Review
  13. Review
  14. Coagulation Profile of COVID-19 Patients.Life (Basel, Switzerland) · 2022
    Review
  15. The suboptimal fibrinolytic response in COVID-19 is dictated by high PAI-1.Journal of thrombosis and haemostasis : JTH · 2022
    Article
  16. Dysregulation of Protein S in COVID-19.Best practice & research. Clinical haematology · 2022
    Review
  17. Article
  18. Article
  19. Review
  20. COVID-19-related laboratory coagulation findings.International journal of laboratory hematology · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

Katrien M J DevreeseCoagulation Laboratory, Department of Laboratory Medicine, Department of Diagnostic Sciences, Ghent University Hospital, Ghent University, Ghent, Belgium.ORCID https://orcid.org/0000-0002-7559-2579
Ghent University Hospital · BE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The alterations in the hemostatic balance in COVID-19 patients are strongly disturbed and contribute to a high prothrombotic status. The high rate of venous thromboembolism in COVID-19 patients goes along with derangements in coagulation laboratory parameters. Hemostasis testing has an important role in diagnosed COVID-19 patients. Elevated D-dimer levels were found to be a crucial laboratory marker in the risk assessment of thrombosis in COVID-19 patients. The diagnostic approach also includes prothrombin time and platelet count. Fibrinogen might give an indication for worsening coagulopathy. Other markers (activated partial thromboplastin time (aPTT), fibrinolysis parameters, coagulation factors, natural anticoagulants, antiphospholipid antibodies and parameters obtained by thromboelastography or thrombin generation assays) have been described as being deranged. These may help to understand the pathophysiology of thrombosis in COVID-19 patients but have currently no place in diagnosis or management in COVID-19 patients. For monitoring the heparin anticoagulant therapy, the anti-Xa assay is suggested, because the severe acute-phase reaction (high fibrinogen and high factor VIII) shortens the aPTT.

Indexed as

Blood Coagulation TestsSARS-CoV-2Antibodies, AntiphospholipidBiomarkersBlood Coagulation FactorsCOVID-19Disseminated Intravascular CoagulationFactor XaFibrin Fibrinogen Degradation ProductsFibrinogenFibrinolysisHeparin, Low-Molecular-WeightHumansPartial Thromboplastin TimePlatelet CountProthrombin TimeAntibodies, AntiphospholipidBiomarkersBlood Coagulation FactorsFactor XaFibrin Fibrinogen Degradation Productsfibrin fragment DFibrinogenHeparin, Low-Molecular-WeightThrombinanticoagulationcoagulation assayscoagulopathycoronavirusCOVID-19hemostasislaboratory teststhromboembolism

Identifiers

PMID34288440
PMCPMC8444785
OpenAlexW3185742445

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.