Evidence map›Paper›PMID 34288391›Full record

ArticleJournal of cellular and molecular medicine2021

The human amniotic fluid stem cell secretome triggers intracellular Ca

Valentina Balducci, Pawan Faris, Carolina Balbi, Ambra Costa, Sharon Negri, Vittorio Rosti, Sveva Bollini, Francesco Moccia

Open access · goldAbstract read
In one paragraph

Article in Journal of cellular and molecular medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
3.8field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 22 citations in OpenAlex.

  1. Review
  2. Article
  3. CaBiomedicines · 2025
    Review
  4. Review
  5. Cracking the Endothelial Calcium (CaInternational journal of molecular sciences · 2023
    Review
  6. Store-Operated CaJournal of clinical medicine · 2023
    Review
  7. New Insights into the Reparative Angiogenesis after Myocardial Infarction.International journal of molecular sciences · 2023
    Review
  8. Article
  9. Review
  10. Review
  11. The Molecular Heterogeneity of Store-Operated CaInternational journal of molecular sciences · 2023
    Review
  12. Intracellular CaFrontiers in physiology · 2023
    Review
  13. Transient Receptor Potential (TRP) Channels in Tumor Vascularization.International journal of molecular sciences · 2022
    Review
  14. CaJournal of translational medicine · 2022
    Article
  15. Review
  16. Nicotinic Acid Adenine Dinucleotide Phosphate Induces Intracellular CaFrontiers in cell and developmental biology · 2022
    Article
  17. Reactive Oxygen Species and Endothelial CaInternational journal of molecular sciences · 2021
    Review
  18. The human amniotic fluid stem cell secretome triggers intracellular CaJournal of cellular and molecular medicine · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Valentina BalducciDepartment of Biology and Biotechnology "Lazzaro Spallanzani", Laboratory of General Physiology, University of Pavia, Pavia, Italy.
Pawan FarisDepartment of Biology and Biotechnology "Lazzaro Spallanzani", Laboratory of General Physiology, University of Pavia, Pavia, Italy.
Carolina BalbiDepartment of Experimental Medicine (DIMES), University of Genova, Genova, Italy.
Ambra CostaDepartment of Experimental Medicine (DIMES), University of Genova, Genova, Italy.
Sharon NegriDepartment of Biology and Biotechnology "Lazzaro Spallanzani", Laboratory of General Physiology, University of Pavia, Pavia, Italy.
Vittorio RostiLaboratory of Biochemistry, Biotechnology and Advanced Diagnostic, Myelofibrosis Study Centre, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy.
Sveva BolliniDepartment of Experimental Medicine (DIMES), University of Genova, Genova, Italy.
Francesco MocciaDepartment of Biology and Biotechnology "Lazzaro Spallanzani", Laboratory of General Physiology, University of Pavia, Pavia, Italy.ORCID 0000-0003-0010-0098
University of Pavia · ITUniversity of Genoa · ITPoliclinico San Matteo Fondazione · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Second trimester foetal human amniotic fluid-derived stem cells (hAFS) have been shown to possess remarkable cardioprotective paracrine potential in different preclinical models of myocardial injury and drug-induced cardiotoxicity. The hAFS secretome, namely the total soluble factors released by cells in their conditioned medium (hAFS-CM), can also strongly sustain in vivo angiogenesis in a murine model of acute myocardial infarction (MI) and stimulates human endothelial colony-forming cells (ECFCs), the only truly recognized endothelial progenitor, to form capillary-like structures in vitro. Preliminary work demonstrated that the hypoxic hAFS secretome (hAFS-CM

Indexed as

SecretomeAmniotic FluidCalciumCells, CulturedCulture Media, ConditionedEndothelial CellsHumansNF-kappa BProtein TransportSignal TransductionStem CellsCalciumCulture Media, ConditionedNF-kappa BangiogenesisCa2+ signallingendothelial colony-forming cellshuman amniotic fluid stem cell secretomeInsP3RsNAADPNF-κBparacrine therapyTRPV4tubulogenesis

Identifiers

PMID34288391
PMCPMC8358861
OpenAlexW3183964759

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.