ArticleAnnals of neurology2021
Postictal Psychosis in Epilepsy: A Clinicogenetic Study.
Article in Annals of neurology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 31 citations in OpenAlex.
- Postictal psychosis concealed during long-term video-electroencephalographic monitoring and unmasked after discharge: A case report.PCN reports : psychiatry and clinical neurosciences · 2026Article
- Genomics and epilepsy: Opportunities to improve understanding and management.Developmental medicine and child neurology · 2026Review
- Managing Recurrent Postictal Worsening of Psychosis in Clozapine-Treated Schizophrenia: A Case Report.Case reports in psychiatry · 2026Article
- Acute catatonia and psychosis in the context of seizure exacerbation in epilepsy: a case report.Frontiers in psychiatry · 2026Article
- Article
- Psychoses of Epilepsy: Unravelling the Phenotypic and Genotypic Features.Annals of neurology · 2025Article
- Monogenic Epilepsies in Adult Epilepsy Clinics and Gene-Driven Approaches to Treatment.Current neurology and neuroscience reports · 2025Review
- Article
- Amnestic syndrome in the course of seronegative limbic encephalitis complicated by drug-resistant epilepsy: a case report.Frontiers in immunology · 2024Article
- The homeless, seizures, and epilepsy: a review.Journal of neural transmission (Vienna, Austria : 1996) · 2023Review
- Psychosis as a Manifestation of Focal Impaired Awareness Seizure in a Geriatric Patient.Cureus · 2023Article
- A case of clinical worsening after stereo-electroencephalographic-guided radiofrequency thermocoagulation in a patient with polymicrogyria.Epilepsy & behavior reports · 2023Article
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Authors and funding
20 authors at 13 institutions in 7 countries.
Funding
Abstract
objectivePsychoses affecting people with epilepsy increase disease burden and diminish quality of life. We characterized postictal psychosis, which comprises about one quarter of epilepsy-related psychoses, and has unknown causation.
methodsWe conducted a case-control cohort study including patients diagnosed with postictal psychosis, confirmed by psychiatric assessment, with available data regarding epilepsy, treatment, psychiatric history, psychosis profile, and outcomes. After screening 3,288 epilepsy patients, we identified 83 with psychosis; 49 had postictal psychosis. Controls were 98 adults, matched by age and epilepsy type, with no history of psychosis. Logistic regression was used to investigate clinical factors associated with postictal psychosis; univariate associations with a p value < 0.20 were used to build a multivariate model. Polygenic risk scores for schizophrenia were calculated.
resultsCases were more likely to have seizure clustering (odds ratio [OR] = 7.59, p < 0.001), seizures with a recollected aura (OR = 2.49, p = 0.013), and a family history of psychiatric disease (OR = 5.17, p = 0.022). Cases showed predominance of right temporal epileptiform discharges (OR = 4.87, p = 0.007). There was no difference in epilepsy duration, neuroimaging findings, or antiseizure treatment between cases and controls. Polygenic risk scores for schizophrenia in an extended cohort of postictal psychosis cases (n = 58) were significantly higher than in 1,366 epilepsy controls (R
interpretationPostictal psychosis occurs under particular circumstances in people with epilepsy with a heightened genetic predisposition to schizophrenia, illustrating how disease biology (seizures) and trait susceptibility (schizophrenia) may interact to produce particular outcomes (postictal psychosis) in a common disease. ANN NEUROL 2021;90:464-476.
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