ArticleMedical physics2021
Feasibility of diffusion weighting with a local inside-out nonlinear gradient coil for prostate MRI.
Article in Medical physics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
8 citing papers in PubMed, 12 citations in OpenAlex.
- SAR-Efficient Sub-Volume Imaging Using Nonlinear Gradient Magnetic Fields.Journal of imaging · 2026Article
- 3D Phase Contrast Using Balanced Steady-State Free Precession (PC-SSFP) for Improved 4D Flow at Clinical Field Strengths.Magnetic resonance in medicine · 2026Article
- A Nonlinear Single Channel Gradient Insert for Prostate Diffusion Imaging.Magnetic resonance in medicine · 2026Article
- Feasibility of strong diffusion encoding and fast readout using a plug-and-play head gradient insert at 7 T.Magnetic resonance in medicine · 2025Article
- Clinical physiology: the crucial role of MRI in evaluation of peripheral artery disease.American journal of physiology. Heart and circulatory physiology · 2024Review
- Use of nonlinear pulsed magnetic fields for spatial encoding in magnetic resonance imaging.Scientific reports · 2024Article
- 3D FRONSAC with PSF reconstruction.Journal of magnetic resonance (San Diego, Calif. : 1997) · 2023Article
- Quantitative diffusion MRI of the abdomen and pelvis.Medical physics · 2022Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
purposeProstate cancer remains the second leading cancer killer of men, yet it is also a disease with a high rate of overtreatment. Diffusion-weighted imaging (DWI) has shown promise as a reliable, grade-sensitive imaging method, but it is limited by low image quality. Currently, DWI quality image is directly related to low gradient amplitudes, since weak gradients must be compensated with long echo times.
methodsWe propose a new type of MRI accessory, an "inside-out" and nonlinear gradient, whose sole purpose is to deliver diffusion encoding to a region of interest. Performance was simulated in OPERA and the resulting fields were used to simulate DWI with two-compartment and kurtosis models. Experiments with a nonlinear head gradient prove the accuracy of DWI and apparent diffusion coefficient (ADC) maps encoded with nonlinear gradients.
resultsSimulations validated thermal and mechanical safety while showing a 5- to 10-fold increase in gradient strength over prostate. With these strengths, lesion contrast to noise ratio in ADC maps approximately doubled for a range of anatomical positions. Proof-of-principle experiments show that spatially varying b-values can be corrected for accurate DWI and ADC.
conclusionsDedicated nonlinear diffusion encoding hardware could improve prostate DWI.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.