Observational studyEuropean journal of clinical investigation2021
Clinical conditions and echocardiographic parameters associated with mortality in COVID-19.
Observational study in European journal of clinical investigation, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 2 syntheses or guidelines pooled it, 38 citations in OpenAlex.
- COVID-19 Patients With Previous Coronary Artery By-Pass Graft Have a Higher Mortality Risk.The American journal of cardiology · 2021Pooled it
- Association between right ventricular dysfunction and mortality in COVID-19 patients: A systematic review and meta-analysis.Clinical cardiology · 2021Pooled it
- Development and validation of a clinical risk model to predict the hospital mortality in ventilated patients with acute respiratory distress syndrome: a population-based study.BMC pulmonary medicine · 2022Trial
- Diagnostic and prognostic value of speckle tracking echocardiography for right ventricular dysfunction in sepsis: a retrospective observational study.BMC cardiovascular disorders · 2025Observational
- Influencing factors of early neurological deterioration in COVID-19 -associated acute ischemic stroke.Scientific reports · 2025Observational
- Characteristics and Outcomes of New-Onset Cardiomyopathy in Hospitalized COVID-19 Patients.Journal of clinical medicine · 2025Article
- Literature Review-Transthoracic Echocardiography, Computed Tomography Angiography, and Their Value in Clinical Decision Making and Outcome Predictions in Patients with COVID-19 Associated Cardiovascular Complications.International journal of environmental research and public health · 2023Review
- The added predictive role of echocardiography in patients with mild or moderate Coronavirus Disease 2019.International journal of cardiology · 2023Article
- Impact of acute TTE-evidenced cardiac dysfunction on in-hospital and outpatient mortality: A multicenter NYC COVID-19 registry study.PloS one · 2023Article
- Cardiac impairments in postacute COVID-19 with sustained symptoms: A review of the literature and proof of concept.Physiological reports · 2022Review
- Review
- Long-Term Prognostic Impact of Right Ventricular Dysfunction in Patients with COVID-19.Journal of personalized medicine · 2022Article
- Cardiovascular System during SARS-CoV-2 Infection.International journal of environmental research and public health · 2022Review
- Acute Coronary Syndrome in Patients with SARS-CoV-2 Infection: Pathophysiology and Translational Perspectives.Translational medicine @ UniSa · 2022Article
- Clinical conditions and echocardiographic parameters associated with mortality in COVID-19.European journal of clinical investigation · 2021Observational
- Prognostic Implications of Right Ventricular Function and Pulmonary Pressures Assessed by Echocardiography in Hospitalized Patients with COVID-19.Journal of personalized medicine · 2021Article
- Comparison of clinical and echocardiographic features of first and second waves of COVID-19 pandemic.The international journal of cardiovascular imaging · 2021Article
- Promoting a Syndemic Approach for Cardiometabolic Disease Management During COVID-19: The CAPISCO International Expert Panel.Frontiers in cardiovascular medicine · 2021Article
- Echocardiography in Coronavirus Disease 2019 Era: A Single Tool for Diagnosis and Prognosis.Journal of cardiovascular echographyReview
- Echocardiographic Assessment of Recovered Patients with Mild COVID-19 Infection: A Case-Control Study.Journal of cardiovascular echographyArticle
Corrections and comments
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Authors and funding
18 authors at 9 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCoronavirus disease 2019 (COVID-19) is a recently recognized viral infective disease which can be complicated by acute respiratory stress syndrome (ARDS) and cardiovascular complications including severe arrhythmias, acute coronary syndromes, myocarditis and pulmonary embolism. The aim of the present study was to identify the clinical conditions and echocardiographic parameters associated with in-hospital mortality in COVID-19.
methodsThis is a multicentre retrospective observational study including seven Italian centres. Patients hospitalized with COVID-19 from 1 March to 22 April 2020 were included into study population. The association between baseline variables and risk of in-hospital mortality was assessed through multivariable logistic regression and competing risk analyses.
resultsOut of 1401 patients admitted at the participating centres with confirmed diagnosis of COVID-19, 226 (16.1%) underwent transthoracic echocardiography (TTE) and were included in the present analysis. In-hospital death occurred in 68 patients (30.1%). At multivariable analysis, left ventricular ejection fraction (LVEF, P < .001), tricuspid annular plane systolic excursion (TAPSE, P < .001) and ARDS (P < .001) were independently associated with in-hospital mortality. At competing risk analysis, we found a significantly higher risk of mortality in patients with ARDS vs those without ARDS (HR: 7.66; CI: 3.95-14.8), in patients with TAPSE ≤17 mm vs those with TAPSE >17 mm (HR: 5.08; CI: 3.15-8.19) and in patients with LVEF ≤50% vs those with LVEF >50% (HR: 4.06; CI: 2.50-6.59).
conclusionsTTE might be a useful tool in risk stratification of patients with COVID-19. In particular, reduced LVEF and reduced TAPSE may help to identify patients at higher risk of death during hospitalization.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.