ReviewImmunology2021
Neutrophils in pregnancy: New insights into innate and adaptive immune regulation.
Review in Immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
41 citing papers in PubMed, 61 citations in OpenAlex.
- Single-cell-level digital twins for preterm birth prevention strategies.Science advances · 2026Article
- MMP8 Promotes NETosis in Gestational Diabetes Mellitus.Antioxidants (Basel, Switzerland) · 2026Article
- Multimodal single-cell protein and RNA profiling unveils dysregulated immature neutrophil dynamics in gestational diabetes mellitus.Communications biology · 2026Article
- Endometrial immune cell profile at the time of frozen embryo transfer as prognostic indicator of live birth.Frontiers in immunology · 2026Observational
- Neutrophil extracellular traps in pregnancy complications.Frontiers in immunology · 2026Review
- Single-cell RNA sequencing of leukocytes at the maternal-fetal interface in physiological and pathological Nodal-deficient pregnancies.Frontiers in immunology · 2026Article
- The role of neutrophil extracellular traps in antiphospholipid syndrome.Frontiers in immunology · 2026Review
- Causal effects of maternal BMI on pregnancy outcomes: a Mendelian randomisation study investigating the mediating role of blood counts.Frontiers in genetics · 2026Article
- Neutrophils at the Maternal-Fetal Interface: Agents of Protection or Destruction?American journal of reproductive immunology (New York, N.Y. : 1989) · 2025Review
- Dynamic changes in neutrophil activation and metabolic profile during pregnancy are associated with gingival inflammation.Scientific reports · 2025Article
- Single-cell-level digital twins for preterm birth prevention strategies.bioRxiv : the preprint server for biology · 2025Article
- Revealing the Complexity of Immunobiological Shifts From Non-Pregnant to Pregnant State.American journal of reproductive immunology (New York, N.Y. : 1989) · 2025Article
- sTLR9 on maternal Circulating immune cells as a negative regulatory phenotype during pregnancy.Cellular and molecular life sciences : CMLS · 2025Article
- Using Comparative Transcriptomics and Histology to Identify Significant Differentially Expressed Genes Associated with Retained Placenta in Humans and Rhesus Macaques (Macaca mulatta).Journal of the American Association for Laboratory Animal Science : JAALAS · 2025Article
- The Role of Chronic Inflammation in Pediatric Cancer.Cancers · 2025Review
- Identification and Immunological Characterization of Cuproptosis Related Genes in Preeclampsia Using Bioinformatics Analysis and Machine Learning.Journal of clinical hypertension (Greenwich, Conn.) · 2025Article
- Immunological reference intervals in pregnancy: longitudinal analysis of adaptive lymphocyte subsets.Frontiers in immunology · 2025Article
- Innate Immune Mechanisms in Normal and Adverse Pregnancy.Advances in experimental medicine and biology · 2025Review
- Exploring genetic associations between immune cells and hypertensive disorder of pregnancy using Mendelian randomization.BMC pregnancy and childbirth · 2024Article
- Quantitative Modeling to Characterize Maternal Inflammatory Response of Histologic Chorioamnionitis in Placental Membranes.American journal of reproductive immunology (New York, N.Y. : 1989) · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
The immunology of pregnancy has been the focus of many studies to better understand how the mother is able to tolerate the presence of a semi-allogeneic fetus. Far from the initial view of pregnancy as a state of immunosuppression, successful fetal development from implantation to birth is now known to be under the control of an intricate balance of immune cells. The balance between pro-inflammatory functions used to promote embryo implantation and placental development and immunosuppressive activity to maintain maternal tolerance of the fetus is an immunological phenotype unique to pregnancy, which is dependent on the time of gestation. Neutrophils are one of a host of innate immune cells detected at the maternal-fetal interface, but very little is known of their function. In this review, we explore the emerging functions of neutrophils during pregnancy and their interactions with and regulation of T cells, a key adaptive immune cell population essential for the establishment of fetal-maternal tolerance.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.