ArticleBrazilian journal of microbiology : [publication of the Brazilian Society for Microbiology]2021
Development and validation of a risk score for predicting positivity of blood cultures and mortality in patients with bacteremia and fungemia.
Article in Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology], 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Time-Sensitive Antibiotic Adjustments in Gram-Negative Bacteremia: A Survival Perspective.Medical science monitor : international medical journal of experimental and clinical research · 2025Article
- Bloodstream Infection and Associated Factors at University of Gondar Comprehensive Specialized Hospital, Northwest Ethiopia, 2023: A Prospective Cross-Sectional Study.BioMed research international · 2025Article
- Economic Impact in the Treatment of Coagulase-Negative Staphylococci Blood Cultures Contamination in a Middle-Income Country.Revista da Sociedade Brasileira de Medicina Tropical · 2025Article
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6 authors.
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Abstract
introductionBacteremia is a major cause of morbidity and mortality in hospitalized patients. Predictors of mortality are critical for the management and survival of hospitalized patients. The objective of this study was to determine the factors related to blood culture positivity and the risk factors for mortality in patients whose blood cultures were collected.
methodsA prospective 2-cohort study (derivation with 784 patients and validation with 380 patients) based on the Pitt bacteremia score for all patients undergoing blood culture collection. The score was obtained from multivariate analysis. The Kaplan-Meier survival curve of the cohort derivation and the cohort validation groups was calculated, and the difference was assessed using a log-rank test. Mortality-related factors were older age, extended hospitalization, > 10% of immature cells in the leukogram, lower mean blood pressure, elevated heart rate, elevated WBC count, and elevated respiratory rate. These continuous variables were dichotomized according to their significance level, and a cut-off limit was created.
resultsThe area under the ROC curve (AUC) was 0.789. The score was validated in a group of 380 patients who were prospectively evaluated.
conclusionProlonged hospitalization, body temperature, and elevated heart rate were related to positive blood cultures. The Pitt score can be used to assess the risk of death; however it can be individualized according to the epidemiology of each hospital.
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