ArticleAnnals of nuclear medicine2021
No effect of Parkinson's disease-polygenic load on striatal density of dopaminergic neuron in healthy subjects.
Article in Annals of nuclear medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed, 1 citations in OpenAlex.
- Molecular Imaging in Parkinsonian Disorders-What's New and Hot?Brain sciences · 2022Review
Corrections and comments
- Erratum issued
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThere has been increasing evidence to support the role of genetic factors in Parkinson's disease (PD).
methodsWe investigated the association between PD-associated polygenic load and striatal density of dopaminergic neuron in healthy subjects. Data used in the preparation of this article were obtained from Parkinson's Progression Markers Initiative database.
resultA total of 151 subjects were included in this study (101 males, 50 females). GRS1, GRS2 and GRS3 were significantly different with the highest scores of GRS1. Multiple regression was done to investigate whether striatal SBRs are influenced by GRSs after adjusting for age and sex. However, none of GRSs were associated with SBRs of the ventral striatum, caudate nucleus and putamen.
conclusionPD risk SNPs weighted by odds ratio for PD were not associated with SBRs measured from SPECT in healthy subjects. Therefore, there is no effect of PD-associated polygenic load on striatal density of dopaminergic neuron in healthy subjects.
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Registered trials
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