Evidence map›Paper›PMID 34287774›Full record

ArticleJournal of general internal medicine2021

Estimation of Admission D-dimer Cut-off Value to Predict Venous Thrombotic Events in Hospitalized COVID-19 Patients: Analysis of the SEMI-COVID-19 Registry.

Carles García-Cervera, Vicente Giner-Galvañ, Philip Wikman-Jorgensen, Jaime Laureiro, Manuel Rubio-Rivas, Anthony Gurjian Arena, Francisco Arnalich-Fernandez, José Luis Beato Pérez, Juan Antonio Vargas Núñez, Jesús Javier González Igual and 16 more

Abstract readMulticenter Study
In one paragraph

Article in Journal of general internal medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Admission biomarkers and COVID-19 mortality: A retrospective study during Vietnam's pandemic peak.Journal of critical care medicine (Universitatea de Medicina si Farmacie din Targu-Mures) · 2026
    Article
  2. Article
  3. Article
  4. Review
  5. Review
  6. Article
  7. COVID-19 and Elevated D-Dimer: A Tale of Caution.Journal of general internal medicine · 2022
    Article
  8. Article
  9. Article
  10. What Is the Impact of Baseline Inflammatory and Hemostatic Indicators with the Risk of Mortality in Severe Inpatients with COVID-19: A Retrospective Study.Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

26 authors.

Carles García-CerveraGeneral Internal Medicine Department, Hospital Universitario San Juan de Alicante, San Juan de Alicante, Alicante, Spain.ORCID 0000-0001-8019-1641
Vicente Giner-GalvañGeneral Internal Medicine Department, Hospital Universitario San Juan de Alicante, San Juan de Alicante, Alicante, Spain.
Philip Wikman-JorgensenGeneral Internal Medicine Department, Hospital Universitario San Juan de Alicante, San Juan de Alicante, Alicante, Spain. wikman.philip@gmail.com.
Jaime LaureiroInternal Medicine Department, 12 de Octubre University Hospital, Madrid, Spain.
Manuel Rubio-RivasInternal Medicine Department, Bellvitge University Hospital-IDIBELL, Barcelona, Spain.
Anthony Gurjian ArenaInternal Medicine Department, Gregorio Marañon University Hospital, Madrid, Spain.
Francisco Arnalich-FernandezInternal Medicine Department, La Paz University Hospital, Madrid, Spain.
José Luis Beato PérezInternal Medicine Department, Albacete University Hospital Complex, Albacete, Spain.
Juan Antonio Vargas NúñezInternal Medicine Department, Puerta de Hierro University Hospital, Majadahonda, Madrid, Spain.
Jesús Javier González IgualInternal Medicine Department, Miguel Servet Hospital, Zaragoza, Spain.
Jesús Díez-ManglanoInternal Medicine Department, Royo Villanova Hospital, Zaragoza, Spain.
Manuel Méndez BailónInternal Medicine Department, San Carlos Clinical Hospital, Madrid, Spain.
María José García BlancoInternal Medicine Department, La Princesa University Hospital, Madrid, Spain.
Santiago J Freire CastroInternal Medicine Department, A Coruña University Hospital, A Coruña, Spain.
Judit Aranda LoboInternal Medicine Department, Consorci Sanitari Integral - Moisès Broggi Hospital, Sant Joan Despí, Barcelona, Spain.
Luis ManzanoInternal Medicine Department, Ramón y Cajal University Hospital, IRYCIS, Madrid, Spain.
Jeffrey Oskar Magallanes GamboaInternal Medicine Department, Nuestra Señora del Prado Hospital, Talavera de la Reina, Toledo, Spain.
Luis Arribas PérezInternal Medicine Department, Zamora Hospital Complex, Zamora, Spain.
Julio González MoralejaInternal Medicine Department, Virgen de la Salud Hospital, Toledo, Spain.
Ruth Calderón HernaizInternal Medicine Department, Infanta Cristina University Hospital, Parla, Madrid, Spain.
Javier García AlegríaInternal Medicine Department, Costa del Sol Hospital, Marbella, Málaga, Spain.
Amara González NoyaInternal Medicine Department, Ourense University Hospital Complex, Ourense, Spain.
Ricardo Gómez HuelgasInternal Medicine Department, Regional University Hospital of Málaga, Biomedical Research Institute of Málaga (IBIMA), University of Málaga (UMA), Málaga, Spain.
Carlos Lumbreras BermejoInternal Medicine Department, 12 de Octubre University Hospital, Madrid, Spain.
Juan Miguel Antón SantosInternal Medicine Department, Infanta Cristina University Hospital, Parla, Madrid, Spain.
SEMI-COVID-19 Network

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundVenous thrombotic events (VTE) are frequent in COVID-19, and elevated plasma D-dimer (pDd) and dyspnea are common in both entities.

objectiveTo determine the admission pDd cut-off value associated with in-hospital VTE in patients with COVID-19.

methodsMulticenter, retrospective study analyzing the at-admission pDd cut-off value to predict VTE and anticoagulation intensity along hospitalization due to COVID-19.

resultsAmong 9386 patients, 2.2% had VTE: 1.6% pulmonary embolism (PE), 0.4% deep vein thrombosis (DVT), and 0.2% both. Those with VTE had a higher prevalence of tachypnea (42.9% vs. 31.1%; p = 0.0005), basal O2 saturation <93% (45.4% vs. 33.1%; p = 0.0003), higher at admission pDd (median [IQR]: 1.4 [0.6-5.5] vs. 0.6 [0.4-1.2] μg/ml; p < 0.0001) and platelet count (median [IQR]: 208 [158-289] vs. 189 [148-245] platelets × 10

conclusionsIn hospitalized patients with COVID-19, a pDd value greater than 3.0 μg/ml can be considered to screen VTE and to consider full-dose anticoagulation.

Indexed as

COVID-19Venous ThromboembolismVenous ThrombosisFibrin Fibrinogen Degradation ProductsHospitalizationHumansRegistriesRetrospective StudiesSARS-CoV-2Fibrin Fibrinogen Degradation Productsfibrin fragment DCOVID-19D-dimerdeep vein thrombosispulmonary embolismSARS-CoV-2venous thrombotic event

Identifiers

PMID34287774
PMCPMC8294343

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.