ArticleJournal of natural medicines2021
Identification of anti-HIV macrocyclic daphnane orthoesters from Wikstroemia ligustrina by LC-MS analysis and phytochemical investigation.
Article in Journal of natural medicines, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Liquid chromatography-mass spectrometry-based automated annotation program-assisted structural characterization of daphnane diterpenoids from Daphne genkwa.Journal of natural medicines · 2026Article
- Identification of Daphnane Diterpenoids from Flower Buds and Blooming Flowers ofPlants (Basel, Switzerland) · 2025Article
- Anti-HIV diterpenoids from Daphne pseudomezereum.Phytochemistry · 2025Article
- Daphnane diterpenoid orthoesters with an odd-numbered aliphatic side chain from Daphne pedunculata.Journal of natural medicines · 2024Article
- Daphnepedunins G and H, anti-HIV macrocyclic 3,4-seco-daphnane orthoesters from Daphne pedunculata.Journal of natural medicines · 2024Article
- LC-MS identification, isolation, and structural elucidation of anti-HIV macrocyclic daphnane orthoesters from Edgeworthia chrysantha.Fitoterapia · 2024Article
- Identification of Daphnane Diterpenoids fromPlants (Basel, Switzerland) · 2023Article
- Tigliane and daphnane diterpenoids from Thymelaeaceae family: chemistry, biological activity, and potential in drug discovery.Journal of natural medicines · 2023Review
- Daphnepedunins A-F, Anti-HIV Macrocyclic Daphnane Orthoester Diterpenoids fromJournal of natural products · 2022Article
- Anti-HIV Macrocyclic Daphnane Orthoesters with an Unusual Macrocyclic Ring fromJournal of natural products · 2022Review
- A feruloylated acylglycerol isolated from Wikstroemia pilosa and its distribution in ten plants of Wikstroemia species.Journal of natural medicines · 2022Article
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Authors and funding
13 authors.
Funding
Abstract
Macrocyclic daphnane orthoesters (MDOs) have attracted significant research interest for the drug discovery to cure HIV infection based on the "Shock and Kill" strategy. In the present study, the first chemical study on Wikstroemia ligustrina (Thymelaeaceae) was carried out by LC-MS analysis and phytochemical investigation. Nine daphnane diterpenoids (1-9) including seven MDOs were detected by LC-MS analysis. Further phytochemical investigation resulted in the isolation and structural elucidation of five daphnanes (1, 2, 5, 8, and 9) with potent anti-HIV activity. Taking the isolated MDO (1) as a model compound, the MS/MS fragmentation pathway was also elucidated.
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