ArticleThe European physical journal. E, Soft matter2021
Morphologies of compressed active epithelial monolayers.
Article in The European physical journal. E, Soft matter, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- A biohybrid system to reconstruct epithelial morphomechanicsMaterials today. Bio · 2026Article
- Vertex models capturing subcellular scales in epithelial tissues.PLoS computational biology · 2025Review
- Graph topological transformations in space-filling cell aggregates.PLoS computational biology · 2024Article
- Mechanical control of neural plate folding by apical domain alteration.Nature communications · 2023Article
- Article
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Authors and funding
3 authors.
Funding
Abstract
Using a three-dimensional active vertex model, we numerically study the shapes of strained unsupported epithelial monolayers subject to active junctional noise due to stochastic binding and unbinding of myosin. We find that while uniaxial, biaxial, and isotropic in-plane compressive strains do lead to the formation of longitudinal, herringbone pattern, and labyrinthine folds, respectively, the villus morphology characteristic of, e.g., the small intestine appears only if junctional tension fluctuations are strong enough to fluidize the tissue. Moreover, the fluidized epithelium features villi even in the absence of compressive strain provided that the apico-basal differential surface tension is large enough. We analyze several details of the different epithelial forms including the role of strain rate and the modulation of tissue thickness across folds. Our results show that even unsupported, non-patterned epithelia can form nontrivial morphologies.
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Registered trials
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