ArticleSupportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer2022
Comorbidity, cognitive dysfunction, physical functioning, and quality of life in older breast cancer survivors.
Article in Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 33 citations in OpenAlex.
- Older breast cancer survivors' exercise and support group program experiences and recommendations from the IMPROVE trial: a qualitative study.BMC cancer · 2026Trial
- Trial
- The association of thigh myosteatosis with lower cognitive function in older cancer survivors.GeroScience · 2026Article
- Screen-detected cognitive impairment, psychological distress, and quality of life in cancer patients undergoing chemotherapy in Yemen.BMC psychology · 2026Article
- Health-related quality of life and predictors in differentiated thyroid cancer patients during the transitional period: A Cross-sectional study.Endocrine · 2026Article
- Disease spectrum and comorbidity patterns of malignant neoplasms: a multi-center hospital-based retrospective analysis of inpatient insurance claims data.Frontiers in oncology · 2026Article
- Article
- Establishing the Ecological Validity of Cognitive Patient Reported Outcome Measures in Breast Cancer Survivors: A Prospective Cohort Study.Psycho-oncology · 2025Article
- Quality of life during the COVID-19 pandemic and survival outcomes among breast cancer survivors.Breast cancer research and treatment · 2025Article
- Association of quality of life in older patients with breast cancer: a cross-sectional study from China.BMJ open · 2025Observational
- A scoping review evaluating physical and cognitive functional outcomes in cancer survivors treated with chemotherapy: charting progress since the 2018 NCI think tank on cancer and aging phenotypes.Journal of cancer survivorship : research and practice · 2024Article
- Association between Cognitive Function and Physical Function, Frailty, and Quality of Life in Older Breast Cancer Survivors.Cancers · 2024Article
- Article
- Mediational roles of stress-coping factors in the relationship between patient-perceived communication quality and physical functioning: racial difference between Chinese and Non-Hispanic White American breast cancer survivors.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2024Article
- Memory Impairments and Wellbeing in Breast Cancer Patients: A Systematic Review.Journal of clinical medicine · 2023Review
- Latent class symptom profiles of colorectal cancer survivors with cancer-related cognitive impairment.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2023Article
- Associations between Physical Activity and Health-Related Quality of Life among Community-Dwelling Older Adults: A Cross-Sectional Study in Urban Greece.Geriatrics (Basel, Switzerland) · 2023Article
- Comorbidities and their management in women with breast cancer-an Australian survey of breast cancer survivors.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2023Article
- Clinicopathological features, genetic alterations, and BRCA1 promoter methylation in Japanese male patients with breast cancer.Breast cancer research and treatment · 2023Article
- Prevalence and clinical correlates of cognitive impairment in adults with plasma cell disorders.Journal of geriatric oncology · 2022Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
purposeOlder breast cancer survivors (BCS) may be at greater risk for cognitive dysfunction and other comorbidities; both of which may be associated with physical and emotional well-being. This study will seek to understand these relationships by examining the association between objective and subjective cognitive dysfunction and physical functioning and quality of life (QoL) and moderated by comorbidities in older BCS.
methodsA secondary data analysis was conducted on data from 335 BCS (stages I-IIIA) who were ≥ 60 years of age, received chemotherapy, and were 3-8 years post-diagnosis. BCS completed a one-time questionnaire and neuropsychological tests of learning, delayed recall, attention, working memory, and verbal fluency. Descriptive statistics and separate linear regression analyses testing the relationship of each cognitive assessment on physical functioning and QoL controlling for comorbidities were conducted.
resultsBCS were on average 69.79 (SD = 3.34) years old and 5.95 (SD = 1.48) years post-diagnosis. Most were stage II (67.7%) at diagnosis, White (93.4%), had at least some college education (51.6%), and reported on average 3 (SD = 1.81) comorbidities. All 6 physical functioning models were significant (p < .001), with more comorbidities and worse subjective attention identified as significantly related to decreased physical functioning. One model found worse subjective attention was related to poorer QoL (p < .001). Objective cognitive function measures were not significantly related to physical functioning or QoL.
conclusionsA greater number of comorbidities and poorer subjective attention were related to poorer outcomes and should be integrated into research seeking to determine predictors of physical functioning and QoL in breast cancer survivors.
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