Evidence map›Paper›PMID 34287678›Full record

ArticleArchives of gynecology and obstetrics2021

The effect of fertility-sparing surgery on sexuality and global quality of life in women with malignant ovarian germ cell and sex cord stromal tumors: an analysis of the CORSETT database of the AGO study group.

Annette Hasenburg, Hellmut Plett, Bernhard Krämer, Elena Braicu, Bastian Czogalla, Michaela Bossart, Susanne Singer, Doris Mayr, Annette Staebler, Andreas du Bois and 10 more

Open access · hybridAbstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Archives of gynecology and obstetrics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.0field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Clinical Challenges in the Management of Malignant Ovarian Germ Cell Tumours.International journal of environmental research and public health · 2023
    Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors at 9 institutions in 1 country.

Annette HasenburgDepartment of Gynecology and Obstetrics, University Medical Center Mainz, Mainz, Germany. annette.hasenburg@unimedizin-mainz.de.ORCID http://orcid.org/0000-0002-1547-4968
Hellmut PlettDepartment of Gynecology and Gynecologic Oncology, Ev. Kliniken Essen-Mitte, Essen, Germany.
Bernhard KrämerDepartment for Women's Health, Tuebingen University Hospital, Tuebingen, Germany.
Elena BraicuDepartment of Gynecology, Campus Virchow Clinic, Charité Berlin, Berlin, Germany.
Bastian CzogallaDepartment of Obstetrics and Gynecology, University Hospital, LMU Munich, Munich, Germany.
Michaela BossartDepartment of Gynecology and Obstetrics, University Medical Center Freiburg, Freiburg, Germany.
Susanne SingerDivision of Epidemiology and Health Care Research, University Medical Center Mainz, Institute of Medical Biostatistics, Epidemiology and Informatics, Mainz, Germany.
Doris MayrInstitute of Pathology, University Hospital, LMU Munich, Munich, Germany.
Annette StaeblerDivision of Gynecologic Pathology, Institute of Pathology and Neuropathology, University of Tübingen, Tuebingen, Germany.
Andreas du BoisDepartment of Gynecology and Gynecologic Oncology, Ev. Kliniken Essen-Mitte, Essen, Germany.
Stefan KommossDepartment for Women's Health, Tuebingen University Hospital, Tuebingen, Germany.
Theresa LinkDepartment of Gynecology and Obstetrics, Medical Faculty, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.
Alexander BurgesDepartment of Obstetrics and Gynecology, University Hospital, LMU Munich, Munich, Germany.
Florian HeitzDepartment of Gynecology and Gynecologic Oncology, Ev. Kliniken Essen-Mitte, Essen, Germany.
Jacqueline KeulDepartment for Women's Health, Tuebingen University Hospital, Tuebingen, Germany.
Fabian TrillschDepartment of Obstetrics and Gynecology, University Hospital, LMU Munich, Munich, Germany.
Philipp HarterDepartment of Gynecology and Gynecologic Oncology, Ev. Kliniken Essen-Mitte, Essen, Germany.
Pauline WimbergerDepartment of Gynecology and Obstetrics, Medical Faculty, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.
Paul BuderathDepartment of Gynecology and Obstetrics, University Hospital Essen, Essen, Germany.
Maximilian KlarDepartment of Gynecology and Obstetrics, University Medical Center Freiburg, Freiburg, Germany.
Kliniken Essen-Mitte · DELMU Klinikum · DEUniversity Children's Hospital Tübingen · DEJohannes Gutenberg University Mainz · DEUniversity Hospital Carl Gustav Carus · DEUniversity Medical Center Freiburg · DECharité - Universitätsmedizin Berlin · DEEssen University Hospital · DEUniversity of Tübingen · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeMalignant ovarian germ cell (MOGCT) and sex cord stromal tumors (SCST) are ovarian neoplasms that affect disproportionally young women. Little is known about the impact of surgical and adjuvant management of these patient's sexual life. This study investigated the effect of fertility-sparing surgery on sexual activity and global quality of life (gQoL) in women with MOGCT and SCST.

methodsCORSETT was an observational, multicenter, mixed retrospective/prospective cohort study of the AGO study group. Women of any age who had been diagnosed with MOGCTs and SCSTs between 2001 and 2011 were asked to complete the Sexual Activity Questionnaire (SAQ) and the EORTC QLQ-C30.

resultsIn total, 355 patients were included. Of these, 152 patients with confirmed histological diagnosis had completed the questionnaires. A total of 106 patients were diagnosed with SCST and 46 with MOGCT. Totally, 83 women (55%) were sexually active. After fertility-sparing surgery, patients had a 2.6 fold higher probability for being sexually active than after non-fertility-conserving treatment (unadjusted odds ratio (OR) 2.6, p = 0.01). After adjustment for age, time since diagnosis, FIGO stage, histology and phase of disease, the OR dropped to 1.8 (p = 0.22). Of the sexually active patients, 35 (42%) reported high levels of discomfort during intercourse; 38% after fertility-sparing; and 58% after non-fertility-sparing surgery (adjusted OR 2.8, p = 0.18). Women with fertility-conserving treatment reported a significantly better global QoL (F

conclusionFertility preserving approaches should be offered to every patient, when oncologically acceptable.

Indexed as

Fertility PreservationOvarian NeoplasmsSex Cord-Gonadal Stromal TumorsFemaleGerm CellsHumansNeoplasm StagingProspective StudiesQuality of LifeRetrospective StudiesSexual BehaviorSexualityFertility-sparing surgeryOvarian germ cell tumorsQuality of lifeSex cord stromal tumorsSexuality

Identifiers

PMID34287678
PMCPMC8553700
OpenAlexW3185402118

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.