ArticlePediatric reports2021
Atypically Protracted Course of Liver Involvement in Kawasaki Disease. Case Report and Literature Review.
Article in Pediatric reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed, 3 citations in OpenAlex.
- Beyond biochemical recovery: rethinking liver dysfunction in Kawasaki disease.Translational pediatrics · 2026Article
- Analysis of the clinical characteristics of patients with Kawasaki disease complicated with cholestasis.BMC pediatrics · 2024Article
- Kawasaki Disease with Hepatobiliary Manifestations.Medicina (Kaunas, Lithuania) · 2022Article
- Kawasaki Disease With Combined Cholestatic Hepatitis andFrontiers in pediatrics · 2021Article
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hypertransaminasemia in patients with Kawasaki disease (KD) is reported to be transient. Here, we describe a child with an atypically protracted course of liver tests abnormalities and review the inherent literature. The patient was hospitalized at age 7-months for isolated hypertransaminasemia detected during a classical KD diagnosed 3 months before, and persistent since then. KD clinical evolution had been favorable, with rapid response to acetylsalicylic acid and intravenous immunoglobulins. Liver enzymes however remained persistently elevated with a fluctuating pattern (ALT > AST levels; peak of AST 186 IU/L and ALT 240 IU/L). During follow-up, the main causes of liver dysfunction had to be excluded through appropriate and extensive laboratory investigations. Transaminases values become steadily normal only 7 months after the acute presentation of KD. Conclusions: Our report shows that an atypically protracted courses of KD-related hypertransaminasemia above the previously reported temporal limits should be taken into account during the stepwise diagnostic approach to the patient's liver dysfunction. Insidious acetylsalycilic acid-hepatotoxicity warrants consideration in the differential diagnosis.
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