Evidence map›Paper›PMID 34287339›Full record

ArticleJournal of developmental biology2021

A Novel Mutation in Cse1l Disrupts Brain and Eye Development with Specific Effects on Pax6 Expression.

Lauren E Blizzard, Chelsea Menke, Shaili D Patel, Ronald R Waclaw, Salil A Lachke, Rolf W Stottmann

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of developmental biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.1field-weighted citation impact, top 56% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Lauren E BlizzardDivision of Human Genetics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA.
Chelsea MenkeDivision of Human Genetics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA.
Shaili D PatelDepartment of Biological Sciences, University of Delaware, Newark, DE 19716, USA.
Ronald R WaclawDivision of Experimental Hematology and Cancer Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA.
Salil A LachkeDepartment of Biological Sciences, University of Delaware, Newark, DE 19716, USA.ORCID 0000-0001-8845-010X
Rolf W StottmannDivision of Human Genetics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA.ORCID 0000-0003-4512-6806
Cincinnati Children's Hospital Medical Center · USUniversity of Delaware · US

Funding

POST TRANSCRIPTIONAL CONTROL OF GENE EXPRESSION IN THE LENS (LENS GENE EXPRESSIONR01EY021505 · NEI · WASHINGTON UNIVERSITY · PI LACHKE, SALIL · 2011 to 2024
$5.3M
Forward Genetic Analysis of Congenital Defects in Cortical Circuits and StructureR01NS085023 · NINDS · CINCINNATI CHILDRENS HOSP MED CTR · PI STOTTMANN, ROLF W · 2014 to 2018
$2.3M
RNA-binding proteins in early eye development.R01EY029770 · NEI · UNIVERSITY OF DELAWARE · PI LACHKE, SALIL · 2019 to 2023
$1.7M
NEI NIH HHS R01029770NEI NIH HHS R01 EY021505NEI NIH HHS R01EY021505NEI NIH HHS R01 EY029770NINDS NIH HHS R01NS085023
6 · The paper itself

Abstract

Forward genetics in the mouse continues to be a useful and unbiased approach to identifying new genes and alleles with previously unappreciated roles in mammalian development and disease. Here, we report a new mouse allele of

Indexed as

anophthalmiaCASCse1lENUmicrophthalmiamutagenesisPax6

Identifiers

PMID34287339
PMCPMC8293161
OpenAlexW3179311457

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.