ReviewDermatopathology (Basel, Switzerland)2021
Histological Patterns of Skin Lesions in Tuberous Sclerosis Complex: A Panorama.
Review in Dermatopathology (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed, 17 citations in OpenAlex.
- A novel synonymous TSC2 mutation in a Chinese family leads to tuberous sclerosis type 2 by disrupting Normal pre-mRNA splicing.Journal, genetic engineering & biotechnology · 2026Article
- Original investigation: evolution of long-term cardiac tumours in patients with tuberous sclerosis.Orphanet journal of rare diseases · 2026Article
- Delayed Diagnosis of Tuberous Sclerosis Complex: A Case Report of Abdominal Distension, Pain, and Severe Anemia.Clinical case reports · 2026Article
- Shagreen Patch in Tuberous Sclerosis Complex at High-Frequency Ultrasound.Diagnostics (Basel, Switzerland) · 2025Article
- [Clinical characterization in patients with neurocutaneous syndrome].Revista medica del Instituto Mexicano del Seguro Social · 2025Observational
- New Insights in Paediatric Dermatopathology-2nd Edition.Dermatopathology (Basel, Switzerland) · 2024Article
- Review of the spectrum of tuberous sclerosis complex: The Saudi Arabian Experience.Neurosciences (Riyadh, Saudi Arabia) · 2024Article
- Article
- Dermoscopy of facial angiofibromas in Fitzpatrick II-III phototype subjects affected by tuberous sclerosis complex.Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI) · 2023Article
- Multiple fibrofolliculomas within a fibrous cephalic plaque in a patient with tuberous sclerosis.JAAD case reports · 2023Article
- Primary TSC2International journal of molecular sciences · 2022Article
- New Insights in Paediatric Dermatopathology.Dermatopathology (Basel, Switzerland) · 2021Article
- Segmental Collagenoma in Tuberous Sclerosis - Think Beyond the Skin: A Rare Case Report.Indian journal of dermatologyArticle
- Acquired Speckled Acrofacial Hypomelanosis: A Novel Case Report.Case reports in dermatologyArticle
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Tuberous Sclerosis Complex (TSC) is a multisystem genetic disease characterized by cutaneous and extracutaneous hamartomas. The diagnosis is based on the association of major and minor criteria, defined by a consensus conference updated in 2012. The clinical examination of the skin is crucial because seven diagnostic criteria are dermatological: four major (hypomelanotic macules, angiofibroma or fibrous cephalic plaques, ungual fibromas, shagreen patches) and three minor criteria (confetti skin lesions, dental enamel pits, intraoral fibromas). Skin biopsy is commonly performed to assert the diagnosis of TSC when the clinical aspect is atypical. Histopathology of TSC cutaneous lesions have been poorly reported until now. In this article, we review the histologic features described in the literature and share our experience of TSC skin biopsies in our pediatric hospital specialized in genetic disorders. Both hypomelanotic lesions and cutaneous hamartomas (angiofibroma/fibrous cephalic plaques, ungual fibromas, shagreen patches) are discussed, including the recent entity called folliculocystic and collagen hamartoma, with a special emphasis on helpful clues for TSC in such lesions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.