Evaluating the Effect of 3'-UTR Variants in

Dmitrii S Bug, Artem V Tishkov, Ivan S Moiseev, Natalia V Petukhova

Open access · goldAbstract read

In one paragraph

Article in Current issues in molecular biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it

0cells of the map it votes in

4citing papers in PubMed

0.5field-weighted citation impact, top 38% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

Genetic Variants and Their Putative Effects on microRNA-Seed Sites: Characterization of the 3' Untranslated Region of Genes Associated with Temperament.Genes · 2023
Article
The 3' UTR polymorphisms rs3742330 in DICER1 and rs10719 in DROSHA genes are not associated with primary open-angle and angle-closure glaucoma: As case-control study.PloS one · 2023
Article
Association of single nucleotide polymorphism miRNA-146a (rs2910164) with increased predisposition to oral squamous cell carcinoma in central India population.Cancer biomarkers : section A of Disease markers · 2023
Article
Regulation of mRNA and miRNA in the response to Salmonella enterica serovar Enteritidis infection in chicken cecum.BMC veterinary research · 2022
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Dmitrii S BugBioinformatics Research Center, Pavlov First Saint Petersburg Medical State University, 197022 St. Petersburg, Russia.

Artem V TishkovBioinformatics Research Center, Pavlov First Saint Petersburg Medical State University, 197022 St. Petersburg, Russia.

Ivan S MoiseevR.M. Gorbacheva Scientific Research Institute of Pediatric Hematology and Transplantation, Pavlov First Saint Petersburg State Medical University, 197022 St. Petersburg, Russia.ORCID 0000-0002-4332-0114

Natalia V PetukhovaBioinformatics Research Center, Pavlov First Saint Petersburg Medical State University, 197022 St. Petersburg, Russia.ORCID 0000-0001-6397-824X

First Pavlov State Medical University of St. Petersburg · RU

Funding

Russian Science Foundation 17-75-20145

6 · The paper itself

Abstract

Untranslated gene regions (UTRs) play an important role in controlling gene expression. 3'-UTRs are primarily targeted by microRNA (miRNA) molecules that form complex gene regulatory networks. Cancer genomes are replete with non-coding mutations, many of which are connected to changes in tumor gene expression that accompany the development of cancer and are associated with resistance to therapy. Therefore, variants that occurred in 3'-UTR under cancer progression should be analysed to predict their phenotypic effect on gene expression, e.g., by evaluating their impact on miRNA target sites. Here, we analyze 3'-UTR variants in

Indexed as

3' Untranslated RegionsGene Expression RegulationRNA InterferenceDEAD-box RNA HelicasesGenetic VariationHumansMesenchymal Stem CellsMicroRNAsOrgan SpecificityPolymorphism, Single NucleotideRibonuclease IIIRNA, Messenger3' Untranslated RegionsDEAD-box RNA HelicasesDICER1 protein, humanDROSHA protein, humanMicroRNAsRibonuclease IIIRNA, Messenger3′-UTR variantDICER1DROSHAgene regulationmiRNAmyelodysplastic syndrometissue-specific profiling

Identifiers

PMID34287278

DOI10.3390/cimb43020044

PMCPMC8929110

OpenAlexW3178201248

What OpenQuestion holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.