Evidence map›Paper›PMID 34287263›Full record

ReviewCurrent issues in molecular biology2021

Current Status of Mining, Modification, and Application of Cellulases in Bioactive Substance Extraction.

Yawei Hu, Guangbo Kang, Lina Wang, Mengxue Gao, Ping Wang, Dong Yang, He Huang

Open access · goldAbstract readReview
In one paragraph

Review in Current issues in molecular biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.4field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Yawei HuDepartment of Biochemical Engineering, School of Chemical Engineering & Technology, Tianjin University, Tianjin 300350, China.
Guangbo KangDepartment of Biochemical Engineering, School of Chemical Engineering & Technology, Tianjin University, Tianjin 300350, China.
Lina WangDepartment of Biochemical Engineering, School of Chemical Engineering & Technology, Tianjin University, Tianjin 300350, China.
Mengxue GaoDepartment of Biochemical Engineering, School of Chemical Engineering & Technology, Tianjin University, Tianjin 300350, China.
Ping WangTianjin Modern Innovative TCM Technology Co. Ltd., Tianjin 300392, China.
Dong YangFrontiers Science Center for Synthetic Biology and Key Laboratory of Systems Bioengineering (Ministry of Education), School of Chemical Engineering & Technology, Tianjin University, Tianjin 300072, China.
He HuangDepartment of Biochemical Engineering, School of Chemical Engineering & Technology, Tianjin University, Tianjin 300350, China.ORCID 0000-0003-3008-4869
Tianjin University · CN

Funding

National Key Research and Development Project 2019YFA0905600Science and Technology Program of Tianjin, China 19YFSLQY00110
6 · The paper itself

Abstract

Cellulases have been used to extract bioactive ingredients from medical plants; however, the poor enzymatic properties of current cellulases significantly limit their application. Two strategies are expected to address this concern: (1) new cellulase gene mining strategies have been promoted, optimized, and integrated, thanks to the improvement of gene sequencing, genomic data, and algorithm optimization, and (2) known cellulases are being modified, thanks to the development of protein engineering, crystal structure data, and computing power. Here, we focus on mining strategies and provide a systemic overview of two approaches based on sequencing and function. Strategies based on protein structure modification, such as introducing disulfide bonds, proline, salt bridges,

Indexed as

Data MiningProtein EngineeringCellulasesChemical FractionationComputational BiologyEnzyme StabilityPlant ExtractsPlants, MedicinalStructure-Activity RelationshipCellulasesPlant Extractsbioactive substancescellulaseextractionmedicinal plantsminingmodification

Identifiers

PMID34287263
PMCPMC8929041
OpenAlexW3178487277

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.