Evidence map›Paper›PMID 34287075›Full record

ArticleAmerican journal of physiology. Regulatory, integrative and comparative physiology2021

Signal-averaged resting sympathetic transduction of blood pressure: is it time to account for prevailing muscle sympathetic burst frequency?

Massimo Nardone, Anthony V Incognito, Muhammad M Kathia, Lucas J Omazic, Jordan B Lee, André L Teixeira, Shengkun Xie, Lauro C Vianna, Philip J Millar

Abstract read
PubMed Publisher
In one paragraph

Article in American journal of physiology. Regulatory, integrative and comparative physiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
3.5field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 26 citations in OpenAlex.

  1. Trial
  2. Resting sympathetic transduction in veterans with PTSD.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2026
    Article
  3. The role of αAmerican journal of physiology. Heart and circulatory physiology · 2025
    Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Neural cardiovascular control is similar in female habitual exercisers and non-exercisers: a pilot study.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2021
    Article
  9. Flattening the sympathetic-vascular transduction curve.American journal of physiology. Regulatory, integrative and comparative physiology · 2021
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 2 countries.

Massimo NardoneDepartment of Human Health and Nutritional Sciences, University of Guelph, Guelph, Ontario, Canada.ORCID 0000-0002-1990-6481
Anthony V IncognitoDepartment of Human Health and Nutritional Sciences, University of Guelph, Guelph, Ontario, Canada.ORCID 0000-0003-1651-2513
Muhammad M KathiaDepartment of Human Health and Nutritional Sciences, University of Guelph, Guelph, Ontario, Canada.
Lucas J OmazicDepartment of Human Health and Nutritional Sciences, University of Guelph, Guelph, Ontario, Canada.
Jordan B LeeDepartment of Human Health and Nutritional Sciences, University of Guelph, Guelph, Ontario, Canada.
André L TeixeiraDepartment of Human Health and Nutritional Sciences, University of Guelph, Guelph, Ontario, Canada.ORCID 0000-0003-4268-7560
Shengkun XieGlobal Management Studies, Ted Rogers School of Management, Ryerson University, Toronto, Ontario, Canada.
Lauro C ViannaNeuroV̇ASQ̇ - Integrative Physiology Laboratory, Faculty of Physical Education, University of Brasilia, Brasilia, Federal District, Brazil.ORCID 0000-0002-5747-0295
Philip J MillarDepartment of Human Health and Nutritional Sciences, University of Guelph, Guelph, Ontario, Canada.ORCID 0000-0002-2177-1061
University of Guelph · CAToronto General Hospital · CAToronto Metropolitan University · CAUniversidade de Brasília · BR

Funding

CIHR
6 · The paper itself

Abstract

Calculating the blood pressure (BP) response to a burst of muscle sympathetic nerve activity (MSNA), termed sympathetic transduction, may be influenced by an individual's resting burst frequency. We examined the relationships between sympathetic transduction and MSNA in 107 healthy males and females and developed a normalized sympathetic transduction metric to incorporate resting MSNA. Burst-triggered signal averaging was used to calculate the peak diastolic BP response following each MSNA burst (sympathetic transduction of BP) and following incorporation of MSNA burst cluster patterns and amplitudes (sympathetic transduction slope). MSNA burst frequency was negatively correlated with sympathetic transduction of BP (

Indexed as

Action PotentialsBlood PressureElectromyographySignal Processing, Computer-AssistedAdolescentAdultBlood Pressure DeterminationCardiovascular SystemElectrocardiographyFemaleHealthy VolunteersHeart RateHumansMaleMiddle AgedMuscle, Skeletalmuscle sympathetic nerve activitysex differencessympathetic transduction

Identifiers

PMID34287075
OpenAlexW3185467839

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.