Trial reportCirculation research2021
Brain Hypoxia Is Associated With Neuroglial Injury in Humans Post-Cardiac Arrest.
Registry-linked trialOpen access · hybridAbstract readClinical Trial
In one paragraph
Trial report in Circulation research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06511999 (Feasibility and Validation of Continuous Measurement of Jugular Venous Oxygen Saturation in Comatose Patients After Cardiac Arrest), which is not on this map. Cited by 40 papers, 4 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
40citing papers in PubMed, 4 pooled it
14.6field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Feasibility and Validation of Continuous Measurement of Jugular Venous Oxygen Saturation in Comatose Patients After Cardiac Arrest
Who cites it
40 citing papers in PubMed, 4 syntheses or guidelines pooled it, 84 citations in OpenAlex.
- The utility of brain biomarkers in predicting survival and neurological outcomes in pediatric patients after cardiac arrest: A systematic review and meta-analysis.Cardiology journal · 2025Pooled it
- Monitoring of Brain Tissue Oxygen Tension in Cardiac Arrest: a Translational Systematic Review from Experimental to Clinical Evidence.Neurocritical care · 2024Pooled it
- Efficacy and safety of corticosteroids in cardiac arrest: a systematic review, meta-analysis and trial sequential analysis of randomized control trials.Critical care (London, England) · 2023Pooled it
- Neurologic Prognostication After Cardiac Arrest Using Brain Biomarkers: A Systematic Review and Meta-analysis.JAMA neurology · 2022Pooled it
- Grey matter volume reduction and its association with brain-enriched blood biomarkers in out-of-hospital cardiac arrest survivors.Scientific reports · 2025Trial
- Intermittent hypoxia preconditioning can attenuate acute hypoxic injury after a sustained normobaric hypoxic exposure: A randomized clinical trial.CNS neuroscience & therapeutics · 2024Trial
- Prehospital high-dose methylprednisolone in resuscitated out-of-hospital cardiac arrest patients (STEROHCA): a randomized clinical trial.Intensive care medicine · 2023Trial
- A randomized, double-blind trial comparing the effect of two blood pressure targets on global brain metabolism after out-of-hospital cardiac arrest.Critical care (London, England) · 2023Trial
- Intracranial Pressure and Brain Tissue Oxygen Trajectories after Cardiac Arrest.Neurocritical care · 2026Article
- Association of EEG Response to Hypertonic Saline and Neurologic Outcomes in Pediatric Acute Brain Injury.Neurocritical care · 2026Article
- Early axonal injury in fentanyl intoxication.Acta neuropathologica communications · 2026Article
- Metabolism-Mediated Regulation of Brain-Heart Interactions.International journal of molecular sciences · 2026Review
- Update on hypoxic-ischemic brain injury: Prognosis and management.World journal of methodology · 2026Review
- Sphingosine-1-Phosphate Receptor 3 Mediated Neuroinflammation is Critically Involved in the Development of Brain Injury Following Cardiac Arrest in Mice.Neurochemical research · 2026Article
- Thrombolytic therapy efficacy in cardiopulmonary resuscitation: Investigating the effect of recombinant tissue plasminogen activator (Review).Molecular medicine reports · 2025Review
- Parthenolide Exerts Protection against Hypoxic-Ischemic Brain Damage in Neonatal Rats by Inhibiting Perk-Mediated Endoplasmic Reticulum Stress.Molecular neurobiology · 2025Article
- The association of the plasma iron and neuron-specific enolase combination and the 28-day neurological outcome after cardiopulmonary resuscitation: a prospective study of iron metabolism disturbances.World journal of emergency medicine · 2025Article
- Characterizing the physiology of circulatory arrest in humans.Nature medicine · 2025Observational
- Machine learning to identify hypoxic-ischemic brain injury on early head CT after pediatric cardiac arrest.Resuscitation · 2025Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors at 5 institutions in 3 countries.
Ryan L HoilandDepartment of Anesthesiology, Pharmacology and Therapeutics, Vancouver General Hospital (R.L.H., D.E.G.), University of British Columbia, Vancouver, Canada.
Philip N AinslieCentre for Heart, Lung, and Vascular Health, School of Health and Exercise Sciences, Faculty of Health and Social Development (R.L.H., P.N.A.), University of British Columbia, Vancouver, Canada.
Cheryl L WellingtonDjavad Mowafaghian Centre for Brain Health, Department of Pathology and Laboratory Medicine, Faculty of Medicine (C.L.W., J.C., S.S.), University of British Columbia, Vancouver, Canada.
Jennifer CooperDjavad Mowafaghian Centre for Brain Health, Department of Pathology and Laboratory Medicine, Faculty of Medicine (C.L.W., J.C., S.S.), University of British Columbia, Vancouver, Canada.
Sophie StukasDjavad Mowafaghian Centre for Brain Health, Department of Pathology and Laboratory Medicine, Faculty of Medicine (C.L.W., J.C., S.S.), University of British Columbia, Vancouver, Canada.
Sonny ThiaraDivision of Critical Care Medicine, Department of Medicine, Vancouver General Hospital (S.T., D.F., N.A.F., D.E.G., M.S.S.), University of British Columbia, Vancouver, Canada.
Denise FosterDivision of Critical Care Medicine, Department of Medicine, Vancouver General Hospital (S.T., D.F., N.A.F., D.E.G., M.S.S.), University of British Columbia, Vancouver, Canada.
Nicholas A FergussonDivision of Critical Care Medicine, Department of Medicine, Vancouver General Hospital (S.T., D.F., N.A.F., D.E.G., M.S.S.), University of British Columbia, Vancouver, Canada.
Edward M ConwayCentre for Blood Research, Life Sciences Institute, University of British Columbia (E.M.C.), University of British Columbia, Vancouver, Canada.
David K MenonDepartment of Clinical Neurosciences, Addenbrookes Hospital, University of Cambridge (D.K.M.).
Peter GooderhamDivision of Neurosurgery, Department of Surgery, Vancouver General Hospital (P.G.), University of British Columbia, Vancouver, Canada.
Veronica Hirsch-ReinshagenInternational Collaboration on Repair Discoveries, Vancouver, BC, Canada (R.L.H., C.L.W., J.C., S.S., V.H.-R.).
Donald E GriesdaleDepartment of Anesthesiology, Pharmacology and Therapeutics, Vancouver General Hospital (R.L.H., D.E.G.), University of British Columbia, Vancouver, Canada.
Mypinder S SekhonDivision of Critical Care Medicine, Department of Medicine, Vancouver General Hospital (S.T., D.F., N.A.F., D.E.G., M.S.S.), University of British Columbia, Vancouver, Canada.
Vancouver Coastal Health · CAVancouver General Hospital · CAAddenbrooke's Hospital · GBInternational Collaboration On Repair Discoveries · CAUniversity of British Columbia · CA
Funding
Canadian Institute of Health Research 437644
Abstract
[Figure: see text].
Indexed as
AdultBiomarkersGlial Fibrillary Acidic ProteinHeart ArrestHumansHypoxia-Ischemia, BrainInterleukin-6MaleNeurofilament ProteinsNeurogliaPhosphopyruvate Hydratasetau ProteinsUbiquitin ThiolesteraseBiomarkersGlial Fibrillary Acidic ProteinInterleukin-6Neurofilament ProteinsPhosphopyruvate Hydratasetau ProteinsUbiquitin Thiolesterasebiomarkerbrain injuryhealthy volunteersinflammationpartial pressure
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
NCT06511999ClinicalTrials.gov
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.