ArticleInternational journal of geriatric psychiatry2021
Impact of agitation in long-term care residents with dementia in the United States.
Article in International journal of geriatric psychiatry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 41 citations in OpenAlex.
- The Associations Between Neuropsychiatric Symptoms and Cognition in People with Dementia: A Systematic Review and Meta-Analysis.Neuropsychology review · 2024Pooled it
- Efficacy of Brexpiprazole on Neuropsychiatric Symptoms and Impact on Caregivers: Pooled Neuropsychiatric Inventory (NPI) Analysis in Patients With Agitation Associated With Dementia due to Alzheimer's Disease.Journal of geriatric psychiatry and neurology · 2026Trial
- Trial
- Brexpiprazole for agitation in clinically relevant patient subgroups: aCurrent medical research and opinion · 2025Trial
- Brexpiprazole's impacts on patients and caregivers in agitation in Alzheimer's dementia.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Trial
- Brexpiprazole for Individual Agitation Symptoms in Alzheimer's Dementia: A Caregiver-Centered Post Hoc Analysis.Neurology and therapy · 2026Article
- Agitation in dementia: Evidence-based consensus recommendations.Journal of the Chinese Medical Association : JCMA · 2026Review
- Observational
- Lessons Learned From the Implementation of a Pragmatic Trial Evaluating Non-Pharmacological Approaches to Dementia Care in US Nursing Homes.Journal of evaluation in clinical practice · 2026Article
- Efficacy of Brexpiprazole in Participants with Agitation Associated with Dementia Due to Alzheimer's Disease: Pooled Analysis of Randomized Controlled Trials.Clinical drug investigation · 2026Article
- The Highly Selective 5-HTCells · 2026Article
- Brexpiprazole for Agitation in Patients with Alzheimer's Dementia with and without Co-Occurring Psychosis: Post Hoc Analysis of Short- and Long-Term Trials.Neuropsychiatric disease and treatment · 2026Article
- Factors Associated With Falls Among Residents Living in Long-Term Care Homes in Ontario.International journal of older people nursing · 2025Article
- Behavioral symptoms and treatment challenges for patients living with dementia: Hospice clinician and caregiver perspectives.Journal of the American Geriatrics Society · 2025Article
- An interpretable machine learning tool for in-home monitoring of agitation episodes in people living with dementia: a proof-of-concept study.EClinicalMedicine · 2025Article
- Detecting Agitated Behaviors in Nursing Home Residents With Dementia Using Electronic Medical Records.Journal of the American Medical Directors Association · 2024Article
- Factors associated with eating performance in nursing home residents living with dementia and other comorbidities.BMC geriatrics · 2024Article
- Establishing the Foundations of Emotional Intelligence in Care Companion Robots to Mitigate Agitation Among High-Risk Patients With Dementia: Protocol for an Empathetic Patient-Robot Interaction Study.JMIR research protocols · 2024Article
- Barriers and facilitators to care for agitation and/or aggression among persons living with dementia in long-term care.BMC geriatrics · 2024Article
- Defining a clinically meaningful within-patient change threshold for the Cohen-Mansfield Agitation Inventory in Alzheimer's dementia.Frontiers in neurology · 2024Article
Corrections and comments
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Authors and funding
10 authors at 6 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesTo describe characteristics and compare clinical outcomes including falls, fractures, infections, and neuropsychiatric symptoms (NPS) among long-term care residents with dementia with and without agitation.
methodsA cross-sectional secondary analysis of administrative healthcare data was conducted whereby residents with dementia residing in a long-term care facility for ≥12 months were identified from the AnalytiCare LLC database (10/2010-06/2014) and were classified into mutually exclusive cohorts (Agitation Cohort or No-Agitation Cohort) based on available agitation-related symptoms. Entropy balancing was used to balance demographic and clinical characteristics between the two cohorts. The impact of agitation on clinical outcomes was compared between balanced cohorts using weighted logistic regression models.
resultsThe study included 6,265 long-term care residents with dementia among whom, 3,313 were included in the Agitation Cohort and 2,952 in the No-Agitation Cohort. Prior to balancing, residents in the Agitation Cohort had greater dementia-related cognitive impairment and clinical manifestations compared to the No-Agitation Cohort. After balancing, residents with and without agitation, respectively, received a median of five and four distinct types of medications (including antipsychotics). Further, compared to residents without agitation, those with agitation were significantly more likely to have a recorded fall (OR = 1.58), fracture (OR = 1.29), infection (OR = 1.18), and other NPS (OR = 2.11).
conclusionsAgitation in long-term care residents with dementia was associated with numerically higher medication use and an increased likelihood of experiencing falls, fractures, infections, and additional NPS compared to residents without agitation, highlighting the unmet need for effective management of agitation symptoms in this population.
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