Evidence map›Paper›PMID 34286837›Full record

Trial reportThe Journal of clinical endocrinology and metabolism2021

Branched-chain Amino Acids and Relationship With Inflammation in Youth With Obesity: A Randomized Controlled Intervention Study.

Ralph G Cosentino, James R Churilla, Samantha Josephson, Zarela Molle-Rios, Md Jobayer Hossain, Wagner L Prado, P Babu Balagopal

Open access · bronzeAbstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in The Journal of clinical endocrinology and metabolism, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed, 1 pooled it
4.5field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 1 synthesis or guideline pooled it, 40 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. The emerging role of branched-chain amino acid metabolism in obesity.International journal of obesity (2005) · 2026
    Review
  4. The Complex Relation of Branched-Chain Amino Acids and Inflammation in the Obesity and Diabetes Context.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2026
    Review
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 1 country.

Ralph G CosentinoDepartment of Clinical and Applied Movement Sciences, University of North Florida, Jacksonville, FL 32224, USA.
James R ChurillaDepartment of Clinical and Applied Movement Sciences, University of North Florida, Jacksonville, FL 32224, USA.
Samantha JosephsonBiomedical Research, Nemours Children's Health System, Jacksonville, FL 32207, USA.
Zarela Molle-RiosDivision of Gastroenterology, Nemours Children's Health System, Wilmington, DE 19802, USA.
Md Jobayer HossainBiomedical Research, Nemours Children's Health System, Wilmington, DE 19802, USA.
Wagner L PradoDepartment of Kinesiology, California State University, San Bernardino, CA 92407, USA.
P Babu BalagopalBiomedical Research, Nemours Children's Health System, Jacksonville, FL 32207, USA.ORCID 0000-0001-6940-0772
Nemours Children's Health System · USUniversity of North Florida · USCalifornia State University, San Bernardino · USMayo Clinic · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

contextElevated concentrations of branched-chain amino acids (BCAA) are strong predictors of type 2 diabetes mellitus (T2DM). Their association with cardiovascular disease (CVD) remains uncertain, particularly in youth.

objectiveWe investigated the role of BCAA and aromatic amino acids (AAA) in obesity, their relationships with novel biomarkers of CVD, and response to a physical activity-based lifestyle intervention (PAL-I) in a randomized controlled study in youth with normal weight (NW) and obesity (OB).

methodsAge (14-18 years) and Tanner stage (≥IV) matched youth (OB, n = 15 and NW, n = 6) were studied; the 15 participants with OB underwent a 3-month randomized controlled PAL-I. Circulating amino acid profile, glucose, insulin, lipids, adiponectin, retinol binding protein-4, fibrinogen, high-sensitivity C-reactive protein, interleukin-6, and 25-hydroxy vitamin-D, along with body composition, were measured at baseline and after PAL-I. Independent t tests, analysis of covariance, and mixed-effect models were used for analysis of the data.

resultsCompared with NW, the concentration of various amino acids, including BCAA and AAA, were altered in OB (P < 0.05). BCAA and AAA showed baseline correlations with body composition and novel biomarkers of CVD, particularly inflammatory factors (all P < 0.05). The PAL-I produced only negligible effects (P > 0.05) on BCAA and AAA. Glutamine, glycine, and aspartic acid decreased with PAL-I (all P < 0.05).

conclusionThe novel finding of the BCAA-inflammation relationship, along with strong correlations with nontraditional biomarkers of CVD, may raise the prospect of BCAA as a biomarker of CVD and evoke a potential link between obesity, T2DM, and CVD.

Indexed as

Insulin ResistanceAdolescentAmino Acids, Branched-ChainBiomarkersBody CompositionCardiovascular DiseasesFemaleFollow-Up StudiesHumansInflammationMaleObesityPrognosisRisk FactorsUnited StatesAmino Acids, Branched-ChainBiomarkersbiomarkersbranched-chain amino acidscardiovascular diseasechildrennutritionobesity

Identifiers

PMID34286837
OpenAlexW3186613427

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.