Evidence map›Paper›PMID 34286713›Full record

ArticleLab on a chip2021

Patterning of interconnected human brain spheroids.

Jae Jung Kim, Mehdi Jorfi, Rudolph E Tanzi, Doo Yeon Kim, Patrick S Doyle, Daniel Irimia

Open access · greenAbstract read
In one paragraph

Article in Lab on a chip, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.6field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 9 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Jae Jung KimCenter for Engineering in Medicine, Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts, USA. daniel_irimia@hms.harvard.edu.
Mehdi JorfiCenter for Engineering in Medicine, Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts, USA. daniel_irimia@hms.harvard.edu.
Rudolph E TanziGenetics and Aging Research Unit, McCance Center for Brain Health, Mass General Institute for Neurodegenerative Disease, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts, USA.
Doo Yeon KimGenetics and Aging Research Unit, McCance Center for Brain Health, Mass General Institute for Neurodegenerative Disease, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts, USA.
Patrick S DoyleDepartment of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA.ORCID 0000-0003-2147-9172
Daniel IrimiaCenter for Engineering in Medicine, Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts, USA. daniel_irimia@hms.harvard.edu.ORCID 0000-0001-7347-2082
Harvard University · USMassachusetts Institute of Technology · US

Funding

Neutrophil Decision Making in Confined Environments in Health and DiseaseR01GM092804 · NIGMS · MASSACHUSETTS GENERAL HOSPITAL · PI IRIMIA, DANIEL · 2010 to 2022
$4.3M
The impact of AD-associated genetic variants in 3D human mixed neural-glial models of ADR01AG061891 · NIA · MASSACHUSETTS GENERAL HOSPITAL · PI KIM, DOO YEON, TANZI, RUDOLPH EMILE · 2019 to 2023
$3.8M
The Alzheimer's Disease Resiliome: Pathway Analysis and Drug Discovery.R01AG062547 · NIA · MASSACHUSETTS GENERAL HOSPITAL · PI HIDE, WINSTON ALEXANDER, KIM, DOO YEON · 2019 to 2023
$3.3M
Human 3D Neuro-Vascular Interaction and Meningeal Lymphatic Models with Application to Alzheimer’s DiseaseR01NS121078 · NINDS · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI CHOI, SE HOON, JORFI, MEHDI · 2021 to 2025
$2.6M
NIA NIH HHS R01 AG061891NIA NIH HHS R01 AG062547NIGMS NIH HHS R01 GM092804NINDS NIH HHS R01 NS121078
6 · The paper itself

Abstract

Brain spheroids are emerging as valuable

Indexed as

Alzheimer Diseasetau ProteinsAmyloid beta-PeptidesBrainHumansNeuronsSpheroids, CellularAmyloid beta-Peptidestau Proteins

Identifiers

PMID34286713
PMCPMC9142085
OpenAlexW3177349027

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.