Evidence map›Paper›PMID 34286634›Full record

ArticleDrug delivery2021

Preparation and characterization of 2-hydroxyethyl starch microparticles for co-delivery of multiple bioactive agents.

Sreekanth Reddy Obireddy, Wing-Fu Lai

Open access · goldAbstract read
In one paragraph

Article in Drug delivery, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
5.0field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 63 citations in OpenAlex.

  1. Trial
  2. Biopolymer-Based Formulations ofPathogens (Basel, Switzerland) · 2026
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  4. Acta pharmaceutica Sinica. B · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 3 countries.

Sreekanth Reddy ObireddyDepartment of Chemistry, Sri Krishnadevaraya University, Anantapur, India.
Wing-Fu LaiShenzhen Key Laboratory of Steroid Drug Discovery and Development, School of Life and Health Sciences, The Chinese University of Hong Kong (Shenzhen), Shenzhen, China.ORCID https://orcid.org/0000-0003-0585-6396
Sri Krishnadevaraya University · INUniversity of Bristol · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The present study reports the generation of 2-hydroxyethyl starch microparticles for co-delivery and controlled release of multiple agents. The obtained microparticles are characterized by using Fourier transform infrared spectroscopy, differential scanning calorimetry, X-ray diffraction analysis, energy-dispersive X-ray spectroscopy, and scanning electron microscopy. By using ofloxacin and ketoprofen as drug models, the release sustainability of the microparticles is examined at pH 1.2, 5.4, and 6.8 at 37 °C, with Fickian diffusion being found to be the major mechanism controlling the kinetics of drug release. Upon being loaded with the drug models, the microparticles show high efficiency in acting against

Indexed as

Bacillus cereusCalorimetry, Differential ScanningChemistry, PharmaceuticalDrug CarriersDrug LiberationEscherichia coliHydrogen-Ion ConcentrationHydroxyethyl Starch DerivativesKetoprofenOfloxacinParticle SizeSolubilityDrug CarriersHydroxyethyl Starch DerivativesKetoprofenOfloxacin2-Hydroxyethyl starchantibacterial activityco-deliveryketoprofenmicroparticlesofloxacinsustained release

Identifiers

PMID34286634
PMCPMC8297403
OpenAlexW3184610750

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.