Evidence map›Paper›PMID 34286421›Full record

ArticleJournal of assisted reproduction and genetics2021

Effects of controlled ovarian stimulation on vascular barrier and endothelial glycocalyx: a pilot study.

Nikolai Hulde, N Rogenhofer, F Brettner, N C Eckert, I Fetz, J-I Buchheim, T Kammerer, A Dendorfer, A Choukèr, K F Hofmann-Kiefer and 2 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of assisted reproduction and genetics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.4field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Nikolai Hulde *Department of Anesthesiology, Heart and Diabetes Center North Rhine-Westphalia, Ruhr University Bochum, Georgstr 11, 32545, Bad Oeynhausen, Germany. nhulde@hdz-nrw.de.ORCID http://orcid.org/0000-0001-5070-0249
N Rogenhofer *Division of Gynecological Endocrinology and Reproductive Medicine, Department of Gynecology and Obstetrics, Ludwig-Maximilians University, Marchioninistr. 15, 81377, Munich, Germany.
F BrettnerDepartment of Anesthesiology, Ludwig-Maximilians University, Marchioninistr. 15, 81377, Munich, Germany.
N C EckertDepartment of Anesthesiology, Ludwig-Maximilians University, Marchioninistr. 15, 81377, Munich, Germany.
I FetzDepartment of Anesthesiology, Ludwig-Maximilians University, Marchioninistr. 15, 81377, Munich, Germany.
J-I BuchheimDepartment of Anesthesiology, Ludwig-Maximilians University, Marchioninistr. 15, 81377, Munich, Germany.
T KammererDepartment of Anesthesiology, Ludwig-Maximilians University, Marchioninistr. 15, 81377, Munich, Germany.
A DendorferWalter-Brendel-Centre of Experimental Medicine, Hospital of the University Munich, Ludwig-Maximilians University, Marchioninistr. 15, 81377, Munich, Germany.
A ChoukèrDepartment of Anesthesiology, Ludwig-Maximilians University, Marchioninistr. 15, 81377, Munich, Germany.
K F Hofmann-KieferDepartment of Anesthesiology, Ludwig-Maximilians University, Marchioninistr. 15, 81377, Munich, Germany.
M Rehm *Department of Anesthesiology, Ludwig-Maximilians University, Marchioninistr. 15, 81377, Munich, Germany.
C Thaler *Division of Gynecological Endocrinology and Reproductive Medicine, Department of Gynecology and Obstetrics, Ludwig-Maximilians University, Marchioninistr. 15, 81377, Munich, Germany.
Ludwig-Maximilians-Universität München · DEHeart and Diabetes Center North Rhine-Westphalia · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeControlled ovarian stimulation significantly amplifies the number of maturing and ovulated follicles as well as ovarian steroid production. The ovarian hyperstimulation syndrome (OHSS) increases capillary permeability and fluid extravasation. Vascular integrity intensely is regulated by an endothelial glycocalyx (EGX) and we have shown that ovulatory cycles are associated with shedding of EGX components. This study investigates if controlled ovarian stimulation impacts on the integrity of the endothelial glycocalyx as this might explain key pathomechanisms of the OHSS.

methodsSerum levels of endothelial glycocalyx components of infertility patients (n=18) undergoing controlled ovarian stimulation were compared to a control group of healthy women with regular ovulatory cycles (n=17).

resultsPatients during luteal phases of controlled ovarian stimulation cycles as compared to normal ovulatory cycles showed significantly increased Syndecan-1 serum concentrations (12.6 ng/ml 6.11

conclusionA shedding of EGX components during ovarian stimulation has not yet been described. Our study suggests that ovarian stimulation may affect the integrity of the endothelial surface layer and increasing vascular permeability. This could explain key features of the OHSS and provide new ways of prevention of this serious condition of assisted reproduction.

Indexed as

Capillary PermeabilityAdultCase-Control StudiesEndothelium, VascularFemaleGlycocalyxHumansInfertility, FemaleOvulation InductionPilot ProjectsSyndecan-1SDC1 protein, humanSyndecan-1Assisted reproductionControlled ovarian stimulation;Endothelial glycocalyxOvarian hyperstimulation syndromeOvulatory cycleSexual hormones

Identifiers

PMID34286421
PMCPMC8490540
OpenAlexW3184721870

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.