ArticleAAPS PharmSciTech2021
Preparation and Characterization of Electrospun Polylactic Acid (PLA) Fiber Loaded with Birch Bark Triterpene Extract for Wound Dressing.
Article in AAPS PharmSciTech, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 46 citations in OpenAlex.
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- Structural Analysis of Regenerated Cellulose Textile Covered with Cellulose Nano Fibers.Polymers · 2025Article
- Accelerating wound healing by biomineralizing crystallization formed from ZIF-8/PLA nanofibers with enhanced revascularization and inflammation reduction.Frontiers in bioengineering and biotechnology · 2025Article
- Multifunctional Microneedle Patch with Diphlorethohydroxycarmalol for Potential Wound Dressing.Tissue engineering and regenerative medicine · 2024Article
- Biomechanical Scaffolds of Decellularized Heart Valves Modified by Electrospun Polylactic Acid.Applied biochemistry and biotechnology · 2024Article
- Drug Delivery Systems of Betulin and Its Derivatives: An Overview.Biomedicines · 2024Review
- Innovative Electrospun Nanofiber Mats Based on Polylactic Acid Composited with Silver Nanoparticles for Medical Applications.Polymers · 2024Article
- Biochemical Approach to Poly(Lactide)-Copper Composite-Impact on Blood Coagulation Processes.Materials (Basel, Switzerland) · 2024Article
- Elastomeric Polyesters in Cardiovascular Tissue Engineering and Organs-on-a-Chip.Biomacromolecules · 2023Review
- Fabrication and Characterization of Polylactic Acid Electrospun Wound Dressing Modified with Polyethylene Glycol, Rosmarinic Acid and Graphite Oxide.Nanomaterials (Basel, Switzerland) · 2023Article
- In situ cell electrospun using a portable handheld electrospinning apparatus for the repair of wound healing in rats.International wound journal · 2022Article
- [Research advances on the application of silk fibroin biomaterials in wound repair].Zhonghua shao shang yu chuang mian xiu fu za zhi · 2022Review
- Essential Oils as Antimicrobial Active Substances in Wound Dressings.Materials (Basel, Switzerland) · 2022Article
- Biomaterials and Extracellular Vesicle Delivery: Current Status, Applications and Challenges.Cells · 2022Review
- Novel 3D-Printed Cell Culture Inserts for Air-Liquid Interface Cell Culture.Life (Basel, Switzerland) · 2022Article
- Article
- Development and Optimization of Hybrid Polymeric Nanoparticles of Apigenin: Physicochemical Characterization, Antioxidant Activity and Cytotoxicity Evaluation.Sensors (Basel, Switzerland) · 2022Article
- Bacterial Cellulose: Production, Characterization, and Application as Antimicrobial Agent.International journal of molecular sciences · 2021Review
- Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Drug-loaded electrospun fibers have attracted increasing attention as a promising wound dressing material due to their capability of preventing from infections and inflammation and maintaining an appropriate environment for wound healing. In this study, polylactic acid (PLA), which is widely used in wound management, was chosen as electrospinnable polymer. A triterpene extract (TE) from the outer bark of birch known for its anti-inflammatory, antiviral, antibacterial, and wound healing effects was chosen to produce TE-loaded PLA electrospun fibers for wound dressing. A binary solvent system of dichloromethane (DCM) and dimethyl sulfoxide (DMSO) was employed, and the ratio of the solvents was optimized for preparing smooth and uniform fibers. The morphology of TE-loaded PLA electrospun fibers was investigated by scanning electron microscopy (SEM). The entrapment of TE in PLA fibers was confirmed by confocal laser scanning microscopy (CLSM). Differential scanning calorimetry (DSC) and X-ray diffraction (XRD) were used to analyze the solid state of TE in PLA fibers. The release behavior of TE was assayed by a shaking flask method for a period of 96 h. The results revealed that TE-loaded electrospun PLA microfibers could be reliably prepared and are promising future candidates in wound therapy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.