Evidence map›Paper›PMID 34286302›Full record

ArticlePatterns (New York, N.Y.)2021

Generating hard-to-obtain information from easy-to-obtain information: Applications in drug discovery and clinical inference.

Matthew Amodio, Dennis Shung, Daniel B Burkhardt, Patrick Wong, Michael Simonov, Yu Yamamoto, David van Dijk, Francis Perry Wilson, Akiko Iwasaki, Smita Krishnaswamy

Open access · goldAbstract read
In one paragraph

Article in Patterns (New York, N.Y.), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
1.7field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 7 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Matthew AmodioDepartment of Computer Science, Yale University, New Haven, CT, USA.
Dennis ShungDepartment of Internal Medicine, Yale University School of Medicine, New Haven, CT, USA.
Daniel B BurkhardtDepartment of Genetics, Yale University School of Medicine, New Haven, CT, USA.
Patrick WongClinical and Translational Research Accelerator, Department of Medicine, Yale University School of Medicine, New Haven, CT, USA.
Michael SimonovClinical and Translational Research Accelerator, Department of Medicine, Yale University School of Medicine, New Haven, CT, USA.
Yu YamamotoClinical and Translational Research Accelerator, Department of Medicine, Yale University School of Medicine, New Haven, CT, USA.
David van DijkDepartment of Cardiology, Yale University School of Medicine, New Haven, CT, USA.
Francis Perry WilsonClinical and Translational Research Accelerator, Department of Medicine, Yale University School of Medicine, New Haven, CT, USA.
Akiko IwasakiDepartment of Immunobiology, Yale University School of Medicine, New Haven, CT, USA.
Smita KrishnaswamyDepartment of Computer Science, Yale University, New Haven, CT, USA.
Yale University · USHoward Hughes Medical Institute · US

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
Finding emergent structure in multi-sample biological data with the dual geometry of cells and features R01GM135929 · NIGMS · MICHIGAN STATE UNIVERSITY · PI BROWN, EDWARD · 2019 to 2022
$1.4M
NCATS NIH HHS UL1 TR001863NIGMS NIH HHS R01 GM135929
6 · The paper itself

Abstract

Often when biological entities are measured in multiple ways, there are distinct categories of information: some information is easy-to-obtain information (EI) and can be gathered on virtually every subject of interest, while other information is hard-to-obtain information (HI) and can only be gathered on some. We propose building a model to make probabilistic predictions of HI using EI. Our feature mapping GAN (FMGAN), based on the conditional GAN framework, uses an embedding network to process conditions as part of the conditional GAN training to create manifold structure when it is not readily present in the conditions. We experiment on generating RNA sequencing of cell lines perturbed with a drug conditioned on the drug's chemical structure and generating FACS data from clinical monitoring variables on a cohort of COVID-19 patients, effectively describing their immune response in great detail.

Indexed as

clinical data monitoringconditional generative modelsdrug perturbationsgenerative adversarial networks

Identifiers

PMID34286302
PMCPMC8276014
OpenAlexW3177362184

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.