Evidence map›Paper›PMID 34286238›Full record

ArticleMaterials today. Bio2021

Topographically guided hierarchical mineralization.

X Deng, A Hasan, S Elsharkawy, E Tejeda-Montes, N V Tarakina, G Greco, E Nikulina, J M Stormonth-Darling, N Convery, J C Rodriguez-Cabello and 5 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Materials today. Bio, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.6field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 24 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Contribution of the ELRs to the development of advancedFrontiers in bioengineering and biotechnology · 2024
    Review
  5. Article
  6. Multiscale static and dynamic mechanical study of theJournal of the Royal Society, Interface · 2023
    Article
  7. Article
  8. Article
  9. Article
  10. Uniaxial Hydroxyapatite Growth on a Self-Assembled Protein Scaffold.International journal of molecular sciences · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 9 institutions in 4 countries.

X DengSchool of Engineering and Materials Science, Queen Mary University of London, London, E1 4NS, UK.
A HasanSchool of Pharmacy, University of Nottingham, Nottingham, NG7 2RD, UK.
S ElsharkawyFaculty of Dentistry, Oral & Craniofacial Sciences, King's College London, London, SE1 9RT, UK.
E Tejeda-MontesMabxience, Insud Pharma, León, Spain.
N V TarakinaMax Planck Institute of Colloids and Interfaces, Potsdam-Golm Science Park, Am Mühlenberg 1 OT Golm, Potsdam, 14476, Germany.
G GrecoLaboratory of Bio-Inspired, Bionic, Nano, Meta, Materials & Mechanics, Department of Civil, Environmental and Mechanical Engineering, University of Trento, Trento, 38122, Italy.
E NikulinaCIC nanoGUNE BRTA, Tolosa Hiribidea, 76, Donostia - San Sebastian, E-20018, Spain.
J M Stormonth-DarlingJames Watt School of Engineering, University of Glasgow, Glasgow, G12 8QQ, UK.
N ConveryJames Watt School of Engineering, University of Glasgow, Glasgow, G12 8QQ, UK.
J C Rodriguez-CabelloBIOFORGE Group, University of Valladolid, CIBER-BBN, Valladolid, Spain.
A BoydeOral Bioengineering, Queen Mary University of London, London, E1 4NS, UK.
N GadegaardJames Watt School of Engineering, University of Glasgow, Glasgow, G12 8QQ, UK.
N M PugnoLaboratory of Bio-Inspired, Bionic, Nano, Meta, Materials & Mechanics, Department of Civil, Environmental and Mechanical Engineering, University of Trento, Trento, 38122, Italy.
M Al-JawadSchool of Dentistry, University of Leeds, Leeds, LS2 9JT, UK.
A MataSchool of Engineering and Materials Science, Queen Mary University of London, London, E1 4NS, UK.
Queen Mary University of London · GBUniversity of Glasgow · GBUniversity of Nottingham · GBCIC nanoGUNE · ESKing's College London · GBMax Planck Institute of Colloids and Interfaces · DEUniversidad de Valladolid · ESUniversity of Leeds · GBUniversity of Trento · IT

Funding

Medical Research Council MR/R015651/1
6 · The paper itself

Abstract

Material platforms based on interaction between organic and inorganic phases offer enormous potential to develop materials that can recreate the structural and functional properties of biological systems. However, the capability of organic-mediated mineralizing strategies to guide mineralization with spatial control remains a major limitation. Here, we report on the integration of a protein-based mineralizing matrix with surface topographies to grow spatially guided mineralized structures. We reveal how well-defined geometrical spaces defined within the organic matrix by the surface topographies can trigger subtle changes in single nanocrystal co-alignment, which are then translated to drastic changes in mineralization at the microscale and macroscale. Furthermore, through systematic modifications of the surface topographies, we demonstrate the possibility of selectively guiding the growth of hierarchically mineralized structures. We foresee that the capacity to direct the anisotropic growth of such structures would have important implications in the design of biomineralizing synthetic materials to repair or regenerate hard tissues.

Indexed as

BoneCrystallizationDental enamelElastin-like recombinamerFluorapatiteHierarchical mineralizationProtein-based biomineralizationSurface topographies

Identifiers

PMID34286238
PMCPMC8273417
OpenAlexW3166741410

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.