ArticleEClinicalMedicine2021
The epidemiology of kidney disease in people of African ancestry with HIV in the UK.
Article in EClinicalMedicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05685810 (Genetic and Clinical Determinants of Cardiovascular Disease, Diabetes, Kidney Disease and Obesity in People of African Ancestry With HIV), which is not on this map. Cited by 13 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Genetic and Clinical Determinants of Cardiovascular Disease, Diabetes, Kidney Disease and Obesity in People of African Ancestry With HIV
Who cites it
13 citing papers in PubMed, 20 citations in OpenAlex.
- Erythroid Atypical Chemokine Receptor 1 Deficiency Aggravates Immune-Mediated Kidney Disease.Journal of the American Society of Nephrology : JASN · 2026Article
- Research Trends in HIV-Associated Nephropathy (HIVAN) from 2015 to 2025: A Bibliometric Analysis Using CiteSpace.HIV/AIDS (Auckland, N.Z.) · 2026Review
- Intersecting social determinants of health, multimorbidity and quality of life in people of Black ethnicities with HIV in South London.AIDS (London, England) · 2025Article
- Antiretroviral therapy in people with HIV and end-stage kidney disease.AIDS (London, England) · 2025Article
- Mapping Vaccination Mindsets among UK Residents of Black Ethnicities with HIV: Lessons from COVID-19.AIDS and behavior · 2025Article
- Cardiovascular disease risk in people of African ancestry with HIV in the United Kingdom.HIV medicine · 2024Article
- Point of care creatinine testing for early detection of renal dysfunction in Tanzanian HIV patients: a study protocol.BMC nephrology · 2024Article
- Pregnancy-associated changes in urinary uromodulin excretion in chronic hypertension.Journal of nephrology · 2024Article
- HbA1c screening for diabetes mellitus and to evaluate diabetic control in people of African ancestry with HIV in South London.International journal of STD & AIDS · 2023Article
- GSTM1 Copy Number and Kidney Disease in People With HIV.Kidney international reports · 2022Article
- Genetic Variants ofKidney international reports · 2022Article
- Sickle Cell Trait and Kidney Disease in People of African Ancestry With HIV.Kidney international reports · 2022Article
- HIV-Associated Nephropathy in 2022.Glomerular diseasesReview
Corrections and comments
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Authors and funding
20 authors at 12 institutions in 2 countries.
Funding
Abstract
backgroundChronic kidney disease (CKD) is a leading cause of morbidity and mortality globally. The risk of CKD is increased in people of African ancestry and with Human Immunodeficiency Virus (HIV) infection.
methodsWe conducted a cross-sectional study investigating the relationship between region of ancestry (East, Central, South or West Africa) and kidney disease in people of sub-Saharan African ancestry with HIV in the UK between May 2018 and February 2020. The primary outcome was renal impairment (estimated glomerular filtration rate [eGFR] of <60 mL/min/1.73 m
findingsOf the 2468 participants (mean age 48.1 [SD 9.8] years, 62% female), 193 had renal impairment, 87 stage 5 CKD, 126 proteinuria, and 43 HIVAN/FSGS or arterionephrosclerosis. After adjusting for demographic characteristics, HIV and several CKD risk factors and with East African ancestry as referent, West African ancestry was associated with renal impairment (prevalence ratio [PR] 2.06 [95% CI 1.40-3.04]) and stage 5 CKD (PR 2.23 [1.23-4.04]), but not with proteinuria (PR 1.27 [0.78-2.05]). West African ancestry (as compared to East/South African ancestry) was also strongly associated with a diagnosis of HIVAN/FSGS or arterionephrosclerosis on kidney biopsy (PR 6.44 [2.42-17.14]).
interpretationOur results indicate that people of West African ancestry with HIV are at increased risk of kidney disease. Although we cannot rule out the possibility of residual confounding, geographical region of origin appears to be a strong independent risk factor for CKD as the association did not appear to be explained by several demographic, HIV or renal risk factors.
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