ReviewHeliyon2021
The neurophysiological basis of bruxism.
Review in Heliyon, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 28 citations in OpenAlex.
- Beyond adrenal suppression: a comprehensive post-marketing safety profile of etomidate from real world data.Frontiers in medicine · 2026Article
- Sleep bruxism: a novel theoretical perspective through the lens of the free energy principle (FEP).Frontiers in behavioral neuroscience · 2026Article
- The mesencephalic trigeminal neuron: electrophysiological insights into function and dysfunction.Frontiers in cellular neuroscience · 2026Review
- Sleep Bruxism and Hypobaric Hypoxia Exposure: Exploring the Physiological Association.Journal of clinical medicine · 2025Review
- Polysomnographic and Electromyographic Evaluation of Sleep Bruxism in Young Colombian Adults: Case-Control Study.Journal of clinical medicine · 2025Article
- Association of cerebrospinal fluid FGF21 with sleep quality in Chinese adults.Sleep & breathing = Schlaf & Atmung · 2025Article
- Oral Clinical and Radiological Signs of Excessive Occlusal Forces in Bruxism.Diagnostics (Basel, Switzerland) · 2025Article
- Comprehensive Gene Expression Analysis Using Human Induced Pluripotent Stem Cells Derived from Patients with Sleep Bruxism: A Preliminary In Vitro Study.International journal of molecular sciences · 2024Article
- The Importance of Genetic Background and Neurotransmission in the Pathogenesis of the Co-Occurrence of Sleep Bruxism and Sleep-Disordered Breathing-Review of a New Perspective.Journal of clinical medicine · 2024Review
- Global Prevalence of Sleep Bruxism and Awake Bruxism in Pediatric and Adult Populations: A Systematic Review and Meta-Analysis.Journal of clinical medicine · 2024Review
- The incidence of dental fractures in the Italian population during the COVID-19 pandemic: An observational study.Journal of conservative dentistry and endodontics · 2024Article
- The ultrastructure of macaque mesencephalic trigeminal nucleus neurons.Experimental brain research · 2024Article
- Inflammatory Markers and Sleep Architecture in Sleep Bruxism-A Case-Control Study.Journal of clinical medicine · 2024Article
- Sleep apnea pathophysiology.Sleep & breathing = Schlaf & Atmung · 2023Review
- Neural Basis of Etiopathogenesis and Treatment of Cervicogenic Orofacial Pain.Medicina (Kaunas, Lithuania) · 2022Review
- Prevalence of bruxism in neurodegenerative disorders in the elderly: A systematic review and meta-analysis.Industrial psychiatry journalReview
- Observational Assessment of the Effect of Sleep Bruxism on Oxyhaemoglobin Saturation:A Preliminary Study.Current health sciences journalArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Mesencephalic trigeminal nucleus (MTN) neurons innervate the stretch receptors of the jaw elevator muscles and periodontal ligament mechanoreceptors, Bruxism activates the MTN. We analyzed how MTN cells are structured, their anatomy and physiology, and the effects of their activation. To induce and maintain sleep, gamma-aminobutyric acid (GABA), an inhibitor neurotransmitter, is released from the ventro-lateral preoptic area of the hypothalamus and acts on the ascending reticular activating system (ARAS) nuclei. The GABA neurotrasmitter induces the entry of chlorine into cells, hyperpolarizing and inhibiting these. MTN cells, on the contrary, are depolarized by GABA, as their receptors are activated upon GABA binding. They "let out" chlorine and activate ARAS cells. MTN cells release glutamate, an excitatory neurotransmitter onto their target cells, in this case onto ARAS cells. During wakefulness, ARAS activation causes cerebral cortex activation; instead, during sleep (sleep bruxism), ARAS activation avoids an excessive reduction in ARAS neurotransmitters, including noradrenaline, dopamine, serotonin, acetylcholine and glutamate. These neurotransmitters, in addition to activating the cerebral cortex, modulate vital functions such as cardiac and respiratory functions. Polysomnography shows that sleep bruxism is always accompanied by cardiac and respiratory activation and, most importantly, by brain function activation. Bruxism is not a parafunction, and it functions to activate ARAS nuclei.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.