ArticleWellcome open research2021
Study protocol for a phase 2A trial of the safety and tolerability of increased dose rifampicin and adjunctive linezolid, with or without aspirin, for HIV-associated tuberculous meningitis [LASER-TBM].
Open access · goldAbstract read
In one paragraph
Article in Wellcome open research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
2.3field-weighted citation impact, top 12% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed, 12 citations in OpenAlex.
- Impact of High-Dose Rifampicin on Linezolid Pharmacokinetics in Tuberculous Meningitis.Open forum infectious diseases · 2026Trial
- Linezolid Population Pharmacokinetic Model in Plasma and Cerebrospinal Fluid Among Patients With Tuberculosis Meningitis.The Journal of infectious diseases · 2024Trial
- A Phase 2A Trial of the Safety and Tolerability of Increased Dose Rifampicin and Adjunctive Linezolid, With or Without Aspirin, for Human Immunodeficiency Virus-Associated Tuberculous Meningitis: The LASER-TBM Trial.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2023Trial
- Advances in the Treatment and Clinical Management Strategies of Tuberculous Meningitis.International journal of general medicine · 2025Review
- Dynamic PET reveals compartmentalized brain and lung tissue antibiotic exposures of tuberculosis drugs.Nature communications · 2024Observational
- Review
- Dynamic PET Reveals Compartmentalized Brain and Lung Tissue Antibiotic Exposures.Research square · 2024Article
- Linezolid does not improve bactericidal activity of rifampin-containing first-line regimens in animal models of TB meningitis.International journal of antimicrobial agents · 2024Article
- Article
- Cognitive Impairment in Tuberculous Meningitis.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2023Article
- Bacterial meningitis in Africa.Frontiers in neurology · 2023Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
38 authors at 6 institutions in 3 countries.
Angharad G DavisThe Francis Crick Institute, Midland Rd, London, NW1 1AT, UK.ORCID https://orcid.org/0000-0001-8914-5094
Sean WassermanWellcome Centre for Infectious Diseases Research in Africa, University of Cape Town, Observatory, Cape Town, 7925, South Africa.ORCID https://orcid.org/0000-0002-3508-6719
Mpumi MaxebengulaWellcome Centre for Infectious Diseases Research in Africa, University of Cape Town, Observatory, Cape Town, 7925, South Africa.
Cari StekWellcome Centre for Infectious Diseases Research in Africa, University of Cape Town, Observatory, Cape Town, 7925, South Africa.
Marise BremerWellcome Centre for Infectious Diseases Research in Africa, University of Cape Town, Observatory, Cape Town, 7925, South Africa.
Remy DaroowalaWellcome Centre for Infectious Diseases Research in Africa, University of Cape Town, Observatory, Cape Town, 7925, South Africa.
Saalikha AzizWellcome Centre for Infectious Diseases Research in Africa, University of Cape Town, Observatory, Cape Town, 7925, South Africa.
Rene GoliathWellcome Centre for Infectious Diseases Research in Africa, University of Cape Town, Observatory, Cape Town, 7925, South Africa.
Stephani StegmannWellcome Centre for Infectious Diseases Research in Africa, University of Cape Town, Observatory, Cape Town, 7925, South Africa.
Sonya KoekemoerWellcome Centre for Infectious Diseases Research in Africa, University of Cape Town, Observatory, Cape Town, 7925, South Africa.
Amanda JacksonWellcome Centre for Infectious Diseases Research in Africa, University of Cape Town, Observatory, Cape Town, 7925, South Africa.
Louise Lai SaiWellcome Centre for Infectious Diseases Research in Africa, University of Cape Town, Observatory, Cape Town, 7925, South Africa.
Yakub KadernaniWellcome Centre for Infectious Diseases Research in Africa, University of Cape Town, Observatory, Cape Town, 7925, South Africa.ORCID https://orcid.org/0000-0003-3787-7167
Thandi SihoyiyaWellcome Centre for Infectious Diseases Research in Africa, University of Cape Town, Observatory, Cape Town, 7925, South Africa.
C Jason LiangBiostatistics Research Branch, National Institute of Allergy and Infectious Diseases, Maryland, USA.
Lori DoddBiostatistics Research Branch, National Institute of Allergy and Infectious Diseases, Maryland, USA.
Paolo DentiDivision of Clinical Pharmacology, Department of Medicine, University of Cape Town, Observatory, 7925, South Africa.
Thomas CredeMitchells Plain Hospital, 8 A Z Berman Drive, Lentegeur, Cape Town, 7785, South Africa.
Jonathan NaudeMitchells Plain Hospital, 8 A Z Berman Drive, Lentegeur, Cape Town, 7785, South Africa.
Patryk SzymanskiMitchells Plain Hospital, 8 A Z Berman Drive, Lentegeur, Cape Town, 7785, South Africa.
Yakoob VallieNew Somerset Hospital, Portswood Rd, Green Point, Cape Town, 8051, South Africa.
Ismail BanderkerNew Somerset Hospital, Portswood Rd, Green Point, Cape Town, 8051, South Africa.
Shiraz MoosaNew Somerset Hospital, Portswood Rd, Green Point, Cape Town, 8051, South Africa.
Peter RaubenheimerDepartment of Medicine, University of Cape Town, Observatory, 7925, South Africa.ORCID https://orcid.org/0000-0002-5416-1286
Rachel P J LaiThe Francis Crick Institute, Midland Rd, London, NW1 1AT, UK.
John JoskaDepartment of Psychiatry and Mental Health, HIV Mental Health Research Unit, Neuroscience Institute, University of Cape Town, Observatory, 7925, South Africa.
Sam NightingaleDepartment of Psychiatry and Mental Health, HIV Mental Health Research Unit, Neuroscience Institute, University of Cape Town, Observatory, 7925, South Africa.
Anna DreyerDepartment of Psychiatry and Mental Health, HIV Mental Health Research Unit, Neuroscience Institute, University of Cape Town, Observatory, 7925, South Africa.ORCID https://orcid.org/0000-0003-1230-3431
Gerda WahlDepartment of Medicine, Water Sisulu University, Mthatha, 5117, South Africa.
Curtis OffiahDepartment of Neuroradiology, Imaging Department, Royal London Hospital, Barts Health NHS Trust, London, E1 1BB, UK.
Isak VorsterDivision of Diagnostic Radiology, University of Cape Town, Groote Schuur Hospital, Observatory, 7925, South Africa.
Sally CandyDivision of Diagnostic Radiology, University of Cape Town, Groote Schuur Hospital, Observatory, 7925, South Africa.
Frances RobertsonMRC/UCT Medical Imaging Research Unit Department of Human Biology, Faculty of Health Sciences, University of Cape Town, Observatory, 7925, South Africa.
Ernesta MeintjesMRC/UCT Medical Imaging Research Unit Department of Human Biology, Faculty of Health Sciences, University of Cape Town, Observatory, 7925, South Africa.
Gary MaartensDivision of Clinical Pharmacology, Department of Medicine, University of Cape Town, Observatory, 7925, South Africa.ORCID https://orcid.org/0000-0003-3080-6606
John BlackDepartment of Medicine, Water Sisulu University, Mthatha, 5117, South Africa.ORCID https://orcid.org/0000-0002-7845-4972
Graeme MeintjesWellcome Centre for Infectious Diseases Research in Africa, University of Cape Town, Observatory, Cape Town, 7925, South Africa.
Robert J WilkinsonThe Francis Crick Institute, Midland Rd, London, NW1 1AT, UK.ORCID https://orcid.org/0000-0002-2753-1800
University of Cape Town · ZASomerset Hospital · ZANational Institute of Allergy and Infectious Diseases · USWalter Sisulu University · ZABarts Health NHS Trust · GBThe Francis Crick Institute · GB
Funding
Translational approaches to improve understanding and outcome in Tuberculous meningitisR01AI145436 · NIAID · HACKENSACK UNIVERSITY MEDICAL CENTER · PI GENGENBACHER, MARTIN ALFONS, LAI, RACHEL PEI JEN · 2020 to 2024
$3.6MCharacterizing the pharmacokinetics of high dose rifampicin and linezolid in a randomized controlled trial for HIV-associated tuberculous meningitisK43TW011421 · FIC · UNIVERSITY OF CAPE TOWN · PI WASSERMAN, SEAN ADAM · 2019 to 2022
$404kFIC NIH HHS K43 TW011421Medical Research Council MR/R008922/1NIAID NIH HHS R01 AI145436Wellcome Trust
Abstract
PubMed holds no abstract for this paper.
Indexed as
AspirinHIVLinezolidRifampicinTuberculous meningitis
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.