Evidence map›Paper›PMID 34285961›Full record

ArticleInternational journal of particle therapy2021

National Protocol for Model-Based Selection for Proton Therapy in Head and Neck Cancer.

Johannes A Langendijk, Frank J P Hoebers, Martin A de Jong, Patricia Doornaert, Chris H J Terhaard, Roel J H M Steenbakkers, Olga Hamming-Vrieze, Jeroen B van de Kamer, Wilko F A R Verbakel, Fatma Keskin-Cambay and 4 more

Open access · diamondAbstract read
In one paragraph

Article in International journal of particle therapy, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
40citing papers in PubMed, 2 pooled it
10.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

40 citing papers in PubMed, 2 syntheses or guidelines pooled it, 77 citations in OpenAlex.

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  9. A multi-toxicity deep learning approach for normal tissue complication probability modelling in head and neck cancer patients receiving radiotherapy.Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 9 institutions in 1 country.

Johannes A LangendijkDepartment of Radiation Oncology, University of Groningen, University Medical Centre Groningen, Groningen, the Netherlands.
Frank J P HoebersDepartment of Radiation Oncology (MAASTRO clinic), GROW School for Oncology and Developmental Biology, Maastricht University Medical Centre, the Netherlands.
Martin A de JongDepartment of Radiation Oncology, Leiden University Medical Centre, Leiden, the Netherlands.
Patricia DoornaertDepartment of Radiation Oncology, University Medical Centre Utrecht, Utrecht University, Utrecht, the Netherlands.
Chris H J TerhaardDepartment of Radiation Oncology, University Medical Centre Utrecht, Utrecht University, Utrecht, the Netherlands.
Roel J H M SteenbakkersDepartment of Radiation Oncology, University of Groningen, University Medical Centre Groningen, Groningen, the Netherlands.
Olga Hamming-VriezeDepartment of Radiation Oncology, the Netherlands Cancer Institute, Amsterdam, the Netherlands.
Jeroen B van de KamerDepartment of Radiation Oncology, the Netherlands Cancer Institute, Amsterdam, the Netherlands.
Wilko F A R VerbakelDepartment of Radiation Oncology, Amsterdam UMC, Vrije Universiteit Amsterdam, Cancer Center Amsterdam, the Netherlands.
Fatma Keskin-CambayDepartment of Radiation Oncology, Erasmus Medical Center, Rotterdam, the Netherlands.
Johannes B ReitsmaJulius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands.
Arjen van der SchaafDepartment of Radiation Oncology, University of Groningen, University Medical Centre Groningen, Groningen, the Netherlands.
Liesbeth J BoersmaDepartment of Radiation Oncology (MAASTRO clinic), GROW School for Oncology and Developmental Biology, Maastricht University Medical Centre, the Netherlands.
Ewoud SchuitJulius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands.
Maastricht University Medical Centre · NLThe Netherlands Cancer Institute · NLUniversity Medical Center Groningen · NLUniversity Medical Center Utrecht · NLUtrecht University · NLErasmus MC · NLLeiden University Medical Center · NLUniversity of Groningen · NLVrije Universiteit Amsterdam · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In the Netherlands, the model-based approach is used to identify patients with head and neck cancer who may benefit most from proton therapy in terms of prevention of late radiation-induced side effects in comparison with photon therapy. To this purpose, a National Indication Protocol Proton therapy for Head and Neck Cancer patients (NIPP-HNC) was developed, which has been approved by the health care authorities. When patients qualify according to the guidelines of the NIPP-HNC, proton therapy is fully reimbursed. This article describes the procedures that were followed to develop this NIPP-HNC and provides all necessary information to introduce model-based selection for patients with head and neck cancer into routine clinical practice.

Indexed as

head and neck cancermodel-based selectionnational indication protocolproton therapyradiation-induced side effects

Identifiers

PMID34285961
PMCPMC8270079
OpenAlexW3176206338

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.