ArticleJournal of experimental pharmacology2021
Evaluation of the Antimalarial Activity of Ethanol Extracts of the Leaves of Three Plant Species Collected from Yayu Coffee Forest Biosphere Reserve, Southwest Ethiopia.
Article in Journal of experimental pharmacology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed, 7 citations in OpenAlex.
- Exploring the potential antimalarial properties, safety profile, and phytochemical composition of Mesua ferrea Linn.PloS one · 2024Article
- Article
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveIn the attempt of searching for potential plant derived antimalarial medicines, the aim of the present study was to examine In vivo antimalarial efficacy of crude ethanol extracts of the leaves of
methodsTo ascertain the safety level of the plant materials, crude extracts underwent oral acute toxicity assessments whereby mice received up to a single dose of 3000 mg/kg. Peter's four day standard antimalarial suppressive test was carried out to determine growth inhibition of parasitemia at tested doses of 400, 600, and 800 mg/kg of the extracts. Survival time of experimental mice and preliminary phytochemical screenings of the extracts were also done according to the standard procedures.
resultsExtracts of the plant materials did not produce severe acute toxic effects in mice that received up to 3000 mg/kg in a single dose. Although complete clearance was not recorded, extracts of the plant materials produced dose dependent suppression of the parasitemia. The highest growth inhibition recorded was by extract of
conclusionThe present study, therefore, suggests that crude ethanol extracts of
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