ArticleClinical epidemiology2021
The Validity of Danish Prescription Data to Measure Use of Aspirin and Other Non-Steroidal Anti-Inflammatory Drugs and Quantification of Bias Due to Non-Prescription Drug Use.
Article in Clinical epidemiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Aspirin or non-steroidal anti-inflammatory drug initiation and subsequent bladder cancer evaluation.Journal of internal medicine · 2026Article
- Non-steroidal anti-inflammatory drug use in patients with varying severity of coronary artery disease.European journal of clinical pharmacology · 2026Article
- Use of prescribed analgesics before and after a standardised chiropractic care programme among patients with lumbar spinal stenosis: a nationwide cohort study.Chiropractic & manual therapies · 2026Article
- Osteoarthritis and analgesic consumption in haemochromatosis HFE C282Y homozygotes with normal or low iron parameters.Nature communications · 2026Article
- The Nationwide Impact of Guidelines for Prophylactic Aspirin Treatment for Preeclampsia.Paediatric and perinatal epidemiology · 2026Article
- Association between low-dose aspirin use and breast cancer recurrence: a Danish nationwide cohort study with up to 23 years of follow-up.British journal of cancer · 2025Article
- Ten-year analgesic utilization patterns and economic implications in Portugal.British journal of clinical pharmacology · 2025Article
- Validity of out-of-hospital and in-hospital cardiac arrest algorithms in the Danish National Patient Registry.Resuscitation plus · 2025Article
- Cardiovascular safety of using non-steroidal anti-inflammatory drugs for gout: a Danish nationwide case-crossover study.Rheumatology international · 2024Article
- Low-dose aspirin use and risk of ovarian cancer: a combined analysis from two nationwide studies in Denmark and Sweden.British journal of cancer · 2024Article
- Use of prescribed analgesics before and after exercise therapy and patient education in patients with knee or hip osteoarthritis.Rheumatology international · 2024Article
- Ibuprofen for Acute Pericarditis and Associated Cardiovascular Risks: A Danish Nationwide, Population-Based Cohort Study.Clinical epidemiology · 2024Article
- Influence of Low-Density Lipoprotein Cholesterol Levels on NSAID-Associated Cardiovascular Risks After Myocardial Infarction: A Population-Based Cohort Study.Clinical epidemiology · 2024Article
- Venous thromboembolism with use of hormonal contraception and non-steroidal anti-inflammatory drugs: nationwide cohort study.BMJ (Clinical research ed.) · 2023Article
- Article
- Antiplatelet drugs and breast cancer risk in a large nationwide Danish case-control study.International journal of cancer · 2023Article
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo evaluate the potential of Danish prescription registries to capture aspirin and non-aspirin non-steroidal anti-inflammatory drug (NSAID) use and to quantitatively evaluate the magnitude of bias from misclassification of true NSAID and aspirin use as apparent non-use in drug outcome studies. PATIENTS AND
methodsIn a population-based cohort study, we retrieved sales statistics for NSAIDs and aspirins based on nationwide data from the Danish Health Data Authority and the Danish National Prescription Registry. We estimated prevalence of recorded and non-recorded NSAID use in the prescription registry and resulting proportions of true NSAID and aspirin use misclassified as apparent non-use from 1999 to 2019 at population and patient levels.
resultsThe prevalence of true use misclassified as non-use (mainly due to over-the-counter use) peaked at 4.7% in 2012 for NSAIDs overall, 5.5% in 2012 for ibuprofen, and at 5.9% in 2002 for high-dose aspirin. Misclassification of other individual NSAIDs was near null. Misclassification of true low-dose aspirin use as non-use declined during the study period but remained around 1% since 2005. In subgroups of cardiac patients, the highest prevalence of true NSAID use misclassified as non-use was 5.0% in 2002 and 4.3% in 2017. Quantitative bias analyses showed how such misclassification of true NSAID and aspirin use as non-use remained minimal both at population and patient levels. In hypothetical examples simulating real study populations with differing exposure prevalence and prevalence of true NSAID and aspirin use misclassified as apparent non-use, the approximate percentage change due to misclassification of use as non-use did not exceed 5% and in most scenarios stayed around 1%.
conclusionThe Danish prescription registries are valid data sources for assessing the effects of aspirin and NSAID use. The influence of non-recorded NSAID and aspirin use on estimates of association is virtually negligible.
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