ArticleDiabetes, metabolic syndrome and obesity : targets and therapy2021
Altered Functional Connectivity Strength of Primary Visual Cortex in Subjects with Diabetic Retinopathy.
Article in Diabetes, metabolic syndrome and obesity : targets and therapy, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Brain-body interactions in systemic diseases: a survey from an imaging perspective.MedScience · 2026Review
- Characteristics of striatal changes in diabetic retinopathy and type 2 diabetes: a resting-state functional magnetic resonance imaging study.Frontiers in human neuroscience · 2026Article
- Multiscale Brain Structural Network Reorganization in Diabetic Retinopathy Using Regional Radiomics Similarity Networks.Diabetes, metabolic syndrome and obesity : targets and therapy · 2026Article
- Transcranial Direct Current Stimulation (tDCS) in Diabetes: A Focused and Mechanistic Review of Symptom and Function Outcomes.Journal of clinical medicine · 2025Review
- Brain white matter microstructural alterations in patients with diabetic retinopathy: an automated fiber-tract quantification study.Quantitative imaging in medicine and surgery · 2025Article
- Functional-structural decoupling in visual network is associated with cognitive decline in patients with type 2 diabetes mellitus: evidence from a multimodal MRI analysis.Brain imaging and behavior · 2024Article
- Aberrant Modular Segregation of Brain Networks in Patients with Diabetic Retinopathy.Diabetes, metabolic syndrome and obesity : targets and therapy · 2024Article
- Exploration of Hippocampal Functional Connectivity Alterations in Patients with High Myopia via Seed-Based Functional Connectivity Analysis.Clinical ophthalmology (Auckland, N.Z.) · 2023Article
- Altered dynamic functional connectivity in the primary visual cortex in patients with primary angle-closure glaucoma.Frontiers in neuroscience · 2023Article
- Exploration of static functional connectivity and dynamic functional connectivity alterations in the primary visual cortex among patients with high myopiaFrontiers in neuroscience · 2023Article
- Abnormal regional spontaneous neural activity and functional connectivity in thyroid-associated ophthalmopathy patients with different activity: a resting-state fMRI study.Frontiers in neurology · 2023Article
- Local-to-Remote Brain Functional Connectivity in Patients with Thyroid-Associated Ophthalmopathy and Assessment of Its Predictive Value Using Machine Learning.International journal of general medicine · 2022Article
- Aberrant Interhemispheric Functional Connectivity in Diabetic Retinopathy Patients.Frontiers in neuroscience · 2021Article
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThe purpose of the study was to find the differences in intrinsic functional connectivity (FC) patterns of the primary visual area (V1) among diabetic retinopathy (DR), diabetes mellitus (DM), and healthy controls (HCs) applying resting-state functional magnetic resonance imaging (rs-fMRI). PATIENTS AND
methodsThirty-five subjects with DR (18 males and 17 females), 22 DM (10 males and 12 females) and 38 HCs (16 males and 22 females) matched for sex, age, and education underwent rs-fMRI scanning. Seed-based FC analysis was performed to find the alterations in the intrinsic FC patterns of V1 in DR compared with DM and HCs.
resultsThe study found that DR patients had a significant lower FC between the bilateral calcarine (CAL)/left lingual gyrus (LING) (BA 17/18) and the left V1, and between the bilateral CAL/left LING (BA 17/18) and the right V1 compared with the HCs. Meanwhile, patients with DR exhibited higher FC strength between the left V1 and the bilateral Caudate/Olfactory/Orbital superior frontal gyrus (OSFG), and between the bilateral Caudate/Olfactory/OSFG (BA 3/4/6) and the right V1. Compared with DM group, patients with DR showed increased FC strength between the right CAL (BA 17/18) and the right V1. DM group exhibited lower FC strength between the left fusiform and the left V1, and between the bilateral CAL and the right V1 when compared with HCs. Moreover, DM group was observed to have higher FC strength between the left superior frontal gyrus and the left V1.
conclusionOur findings indicated that DR patients exhibited FC disruptions between V1 and higher visual regions at rest, which may reflect the aberrant information communication in the V1 area of DR individuals. The findings offer important insights into the neuromechanism of vision disorder in DR patients.
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