Evidence map›Paper›PMID 34285351›Full record

ArticlePediatric research2022

Retinopathy of prematurity shows alterations in Vegfa

Olachi J Mezu-Ndubuisi, Yong-Seok Song, Erica Macke, Hailey Johnson, Ginika Nwaba, Akihiro Ikeda, Nader Sheibani

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pediatric research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.7field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Article
  3. Ref-1 redox activity regulates retinal neovascularization by modulating transcriptional activation of HIF-1α.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2025
    Article
  4. Review
  5. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Olachi J Mezu-NdubuisiDepartment of Pediatrics, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA. olachimezu@pediatrics.wisc.edu.
Yong-Seok SongDepartment of Ophthalmology and Visual Sciences, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.
Erica MackeDepartment of Medical Genetics, University of Wisconsin-Madison, Madison, WI, USA.
Hailey JohnsonDepartment of Pediatrics, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.
Ginika NwabaVanderbilt University, Nashville, TN, USA.
Akihiro IkedaDepartment of Medical Genetics, University of Wisconsin-Madison, Madison, WI, USA.
Nader SheibaniDepartment of Ophthalmology and Visual Sciences, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.
University of Wisconsin–Madison · USVanderbilt University · US

Funding

UW COMPREHENSIVE CANCER CENTER SUPPORTP30CA014520 · NCI · UNIVERSITY OF WISCONSIN-MADISON · PI Christian Capitini · 1985 to 2026
$142.6M
UW Vision Research Core - Administrative CoreP30EY016665 · NEI · UNIVERSITY OF WISCONSIN-MADISON · PI Donna M Peters · 2005 to 2026
$12.6M
Molecular Genetics of Age-Dependent Retinal DegenerationR01EY022086 · NEI · UNIVERSITY OF WISCONSIN-MADISON · PI AKIHIRO IKEDA · 2012 to 2026
$6.1M
Investigating oxygen metabolism in diabetic retinopathyR01EY026078 · NEI · NORTHWESTERN UNIVERSITY · PI SHEIBANI, NADER, ZHANG, HAO F · 2016 to 2020
$2.3M
Mechanism of intravitreal VEGF-A165a and topical calcitriol for the treatment of retinopathy of prematurityK08EY032203 · NEI · UNIVERSITY OF WISCONSIN-MADISON · PI MEZU-NDUBUISI, OLACHI JOY · 2021 to 2025
$1.2M
Role of chondroitin sulfate proteoglycans in photoreceptor - RPE interactionR21EY029067 · NEI · UNIVERSITY OF WISCONSIN-MADISON · PI IKEDA, AKIHIRO · 2018 to 2019
$414k
NCI NIH HHS P30 CA014520NEI NIH HHS K08 EY032203NEI NIH HHS L40 EY025868NEI NIH HHS P30 EY016665NEI NIH HHS R01 EY022086NEI NIH HHS R01 EY026078NEI NIH HHS R21 EY029067
6 · The paper itself

Abstract

backgroundPathologic ocular neovascularization in retinopathy of prematurity (ROP) and other proliferative retinopathies are characterized by dysregulation of vascular endothelial growth factor-A (VEGF-A). A study of Vegfa isoform expression during oxygen-induced ischemic retinopathy (OIR) may enhance our understanding of Vegf dysregulation.

methodsFollowing induction of OIR, immunohistochemistry and polymerase chain reaction (PCR) was performed on room air (RA) and OIR mice.

resultsTotal Vegfa messenger RNA (mRNA) expression was stable in RA mice, but increased in OIR mice with a peak at postnatal day 17 (P17), before returning to RA levels. Vegfa

conclusionsVegfa IMPACT: Vegfa

Indexed as

Retinal NeovascularizationRetinopathy of PrematurityAnimalsAnimals, NewbornDisease Models, AnimalMiceMice, Inbred C57BLNeovascularization, PathologicOxygenProtein IsoformsRNA, MessengerVascular Endothelial Growth Factor AOxygenProtein IsoformsRNA, MessengerVascular Endothelial Growth Factor Avascular endothelial growth factor A, mouseVEGFA protein, human

Identifiers

PMID34285351
PMCPMC8770670
OpenAlexW3185854778

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.