Evidence map›Paper›PMID 34285285›Full record

ArticleScientific reports2021

MiR-486-3p was downregulated at microRNA profiling of adrenals of multiple endocrine neoplasia type 1 mice, and inhibited human adrenocortical carcinoma cell lines.

Su-Chen Li, Azita Monazzam, Masoud Razmara, Xia Chu, Peter Stålberg, Britt Skogseid

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.6field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Cancer biology & therapy · 2024
    Article
  5. Article
  6. Review
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Su-Chen LiDepartment of Medical Sciences, Uppsala University, 751 85, Uppsala, Sweden.
Azita MonazzamDepartment of Medical Sciences, Uppsala University, 751 85, Uppsala, Sweden.
Masoud RazmaraDepartment of Medical Sciences, Uppsala University, 751 85, Uppsala, Sweden.
Xia ChuDepartment of Medical Sciences, Uppsala University, 751 85, Uppsala, Sweden.
Peter StålbergDepartment of Surgical Sciences, Uppsala University, Uppsala, Sweden.
Britt SkogseidDepartment of Medical Sciences, Uppsala University, 751 85, Uppsala, Sweden. britt.skogseid@medsci.uu.se.
Uppsala University · SEScience for Life Laboratory · SE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Adrenocortical carcinoma is a rare aggressive disease commonly recurring regardless of radical surgery. Although data on genomic alterations in malignant tumors are accumulating, knowledge of molecular events of importance for initiation of adrenocortical transformation is scarce. In an attempt to recognize early molecular alterations, we used adrenals from young multiple endocrine neoplasia type 1 conventional knock-out mice (Men1

Indexed as

Down-RegulationAdrenal Cortex NeoplasmsAdrenocortical CarcinomaAnimalsCell Line, TumorCell ProliferationDeep LearningFatty Acid Synthase, Type IFemaleGene Expression ProfilingGene Expression Regulation, NeoplasticHumansMaleMiceMice, KnockoutMicroRNAsFASN protein, humanFatty Acid Synthase, Type IMen1 protein, mouseMicroRNAsMIRN486 microRNA, humanProto-Oncogene Proteins

Identifiers

PMID34285285
PMCPMC8292366
OpenAlexW3186323800

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.