ArticleNature communications2021
Dysfunction of the key ferroptosis-surveilling systems hypersensitizes mice to tubular necrosis during acute kidney injury.
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Article in Nature communications, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 175 papers, 1 of them a synthesis that pooled it.
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175citing papers in PubMed, 1 pooled it
27.2field-weighted citation impact, top 1% of its field
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Who cites it
175 citing papers in PubMed, 1 synthesis or guideline pooled it, 243 citations in OpenAlex.
- Ferroptosis in eye diseases: a systematic review.Eye (London, England) · 2025Pooled it
- Sirtuin 5-mediated desuccinylation of PRDX6 inhibits ferroptosis and alleviates sepsis-associated acute kidney injury.Redox report : communications in free radical research · 2026Article
- Article
- Ferroptosis in kidney disease.Nature reviews. Nephrology · 2026Review
- Mechanisms of regeneration and maladaptive repair in acute kidney injury.Nature reviews. Nephrology · 2026Review
- Ferroptotic propagation: from single-cell execution to tissue-scale death programs.Cell research · 2026Review
- Mechanisms underlying propagation of ferroptotic cell death.Nature cell biology · 2026Review
- Alpha-Mangostin in Acute Kidney Injury: Molecular Mechanisms, Regulated Cell Death, and Translational Opportunities.Antioxidants (Basel, Switzerland) · 2026Review
- Remodeling of ferroptotic necroinflammation by dexamethasone in acute tubular necrosis.Cell death & disease · 2026Article
- Review
- Ligustroflavone protects against acute kidney injury by inhibiting ferroptosis via acting on GSK3β/NRF2 signaling.International journal of molecular medicine · 2026Article
- Regulation Progresses of Selenium Improving Intestinal and Extra-Intestinal Tissues Health Through Regulating Gut Microbiota.Biology · 2026Review
- The Dual Role of Ferroptosis in Cancer: Molecular Mechanisms, Microenvironment Crosstalk, and Precision Therapeutics.Cancers · 2026Review
- Metal-dependent regulated cell death: Molecular architecture and translational frontiers.iMeta · 2026Review
- Lipophilic Statins Deplete GPX4 to Promote Ferroptosis and Sensitize Cancer Cells to Immune Checkpoint Blockade.Molecular cancer therapeutics · 2026Article
- Macrophage ferritin heavy chain/α-synuclein regulatory axis modulates ferroptosis during kidney injury.JCI insight · 2026Article
- The phospholipid profile of T cells shapes ACSL4 dependency and ferroptosis sensitivity of naive, effector, and memory T cells.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Ferroptosis in diabetic retinopathy: cellular heterogeneity, progression, and therapeutic targets.Molecular biology reports · 2026Review
- IFI16 is essential to linking DNA damage and ferroptosis in acute kidney injury.Cell death & disease · 2026Article
- The Multilayered Landscape of Ferroptosis: Plasticity, Propagation, and Evolutionary Perspectives.Antioxidants (Basel, Switzerland) · 2026Review
115 more citing papers are in PubMed but not listed here.
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Authors and funding
32 authors at 13 institutions in 6 countries.
Wulf Tonnus *Division of Nephrology, Department of Internal Medicine 3, University Hospital Carl Gustav Carus at the Technische Universität Dresden, Dresden, Germany.ORCID 0000-0002-9728-1413
Claudia Meyer *Division of Nephrology, Department of Internal Medicine 3, University Hospital Carl Gustav Carus at the Technische Universität Dresden, Dresden, Germany.ORCID 0000-0002-8722-0772
Christian SteinebachPharmaceutical Institute, Pharmaceutical Chemistry I, University of Bonn, Bonn, Germany.ORCID 0000-0001-5638-1955
Alexia BelavgeniDivision of Nephrology, Department of Internal Medicine 3, University Hospital Carl Gustav Carus at the Technische Universität Dresden, Dresden, Germany.
Anne von MässenhausenDivision of Nephrology, Department of Internal Medicine 3, University Hospital Carl Gustav Carus at the Technische Universität Dresden, Dresden, Germany.
Nadia Zamora GonzalezDivision of Nephrology, Department of Internal Medicine 3, University Hospital Carl Gustav Carus at the Technische Universität Dresden, Dresden, Germany.
Francesca MaremontiDivision of Nephrology, Department of Internal Medicine 3, University Hospital Carl Gustav Carus at the Technische Universität Dresden, Dresden, Germany.
Florian GembardtDivision of Nephrology, Department of Internal Medicine 3, University Hospital Carl Gustav Carus at the Technische Universität Dresden, Dresden, Germany.ORCID 0000-0003-2739-345X
Nina HimmerkusInstitute of Physiology, Christian-Albrecht-University Kiel, Kiel, Germany.
Markus LatkDivision of Nephrology, Department of Internal Medicine 3, University Hospital Carl Gustav Carus at the Technische Universität Dresden, Dresden, Germany.
Sophie LockeDivision of Nephrology, Department of Internal Medicine 3, University Hospital Carl Gustav Carus at the Technische Universität Dresden, Dresden, Germany.
Julian MarschnerDivision of Nephrology, Department of Medicine IV, University Hospital LMU Munich, Munich, Germany.
Wenjun LiDepartment of Surgery, Washington University, Saint Louis, MO, USA.
Spencer ShortDepartment of Chemistry and Biomolecular Sciences, University of Ottawa, Ottawa, ON, Canada.ORCID 0000-0002-6839-1568
Sebastian DollInstitute of Metabolism and Cell Death, Helmholtz Zentrum München, Neuherberg, Germany.
Irina IngoldInstitute of Metabolism and Cell Death, Helmholtz Zentrum München, Neuherberg, Germany.
Bettina PronethInstitute of Metabolism and Cell Death, Helmholtz Zentrum München, Neuherberg, Germany.ORCID 0000-0002-4119-9437
Christoph DanielDepartment of Nephropathology, Friedrich-Alexander University (FAU) Erlangen-Nürnberg, Erlangen, Germany.ORCID 0000-0002-6803-4755
Nazanin KabganiClinic for Renal and Hypertensive Disorders, Rheumatological and Immunological Disease, University Hospital of the RWTH Aachen, Aachen, Germany.
Rafael KramannClinic for Renal and Hypertensive Disorders, Rheumatological and Immunological Disease, University Hospital of the RWTH Aachen, Aachen, Germany.
Stephen MotikaDepartment of Pathobiology, University of Illinois, Urbana, IL, USA.
Paul J HergenrotherDepartment of Pathobiology, University of Illinois, Urbana, IL, USA.ORCID 0000-0001-9018-3581
Stefan R BornsteinDepartment of Internal Medicine 3, University Hospital Carl Gustav Carus at the Technische Universität Dresden, Dresden, Germany.ORCID 0000-0002-5211-2536
Christian HugoDivision of Nephrology, Department of Internal Medicine 3, University Hospital Carl Gustav Carus at the Technische Universität Dresden, Dresden, Germany.
Jan Ulrich BeckerInstitute of Pathology, University Hospital of Cologne, Cologne, Germany.
Kerstin AmannDepartment of Nephropathology, Friedrich-Alexander University (FAU) Erlangen-Nürnberg, Erlangen, Germany.
Hans-Joachim AndersDivision of Nephrology, Department of Medicine IV, University Hospital LMU Munich, Munich, Germany.
Daniel KreiselDepartment of Surgery, Washington University, Saint Louis, MO, USA.
Derek PrattDepartment of Chemistry and Biomolecular Sciences, University of Ottawa, Ottawa, ON, Canada.ORCID 0000-0002-7305-745X
Michael GütschowPharmaceutical Institute, Pharmaceutical Chemistry I, University of Bonn, Bonn, Germany.
Marcus ConradInstitute of Metabolism and Cell Death, Helmholtz Zentrum München, Neuherberg, Germany.ORCID 0000-0003-1140-5612
Andreas LinkermannDivision of Nephrology, Department of Internal Medicine 3, University Hospital Carl Gustav Carus at the Technische Universität Dresden, Dresden, Germany. andreas.linkermann@ukdd.de.ORCID 0000-0001-6287-9725
University Hospital Carl Gustav Carus · DEHelmholtz Zentrum München · DEFriedrich-Alexander-Universität Erlangen-Nürnberg · DELMU Klinikum · DEUniversity of Bonn · DEUniversity of Illinois Urbana-Champaign · USUniversity of Ottawa · CAWashington University in St. Louis · USChristian-Albrechts-Universität zu Kiel · DEErasmus MC · NLNanyang Technological University · SGRWTH Aachen University · DEUniversity Hospital Cologne · DE
Funding
No grant is acknowledged in the PubMed record.
Abstract
Acute kidney injury (AKI) is morphologically characterized by a synchronized plasma membrane rupture of cells in a specific section of a nephron, referred to as acute tubular necrosis (ATN). Whereas the involvement of necroptosis is well characterized, genetic evidence supporting the contribution of ferroptosis is lacking. Here, we demonstrate that the loss of ferroptosis suppressor protein 1 (Fsp1) or the targeted manipulation of the active center of the selenoprotein glutathione peroxidase 4 (Gpx4
Indexed as
Acute Kidney InjuryAnimalsApoptosis Regulatory ProteinsCisplatinDisease Models, AnimalEpithelial CellsFemaleFerroptosisGene Knockdown TechniquesHeart TransplantationHT29 CellsHumansImidazolesIndolesKidney TubulesMaleAIFM3 protein, humanApoptosis Regulatory ProteinsCisplatinferroptosis suppressor protein 1, mouseglutathione peroxidase 4, mouseImidazolesIndolesMitochondrial Proteinsnecrostatin-1OxidoreductasesPhospholipid Hydroperoxide Glutathione PeroxidaseReceptor-Interacting Protein Serine-Threonine KinasesRipk1 protein, mouse
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