ArticleNature communications2021
Early-life social experience affects offspring DNA methylation and later life stress phenotype.
Article in Nature communications, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
19 citing papers in PubMed.
- Cooperative care influences genome-wide levels of DNA methylation in nestling chestnut-crowned babblers.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2026Article
- Further integrating social context into comparative and environmental physiology.The Journal of experimental biology · 2026Review
- Social bonds decrease epigenetic age in male bottlenose dolphins.Communications biology · 2025Article
- Childhood trauma cortisol and immune cell glucocorticoid transcript levels are associated with increased risk for suicidality in adolescence.Molecular psychiatry · 2025Article
- Cost-effective solutions for high-throughput enzymatic DNA methylation sequencing.PLoS genetics · 2025Article
- De novo whole-genome assembly of the critically endangered southern muriqui (Brachyteles arachnoides).G3 (Bethesda, Md.) · 2025Article
- Is Early Life Adversity Associated With Adult Stress in a Wild Rodent?Ecology and evolution · 2025Article
- Stay social, stay young: a bioanthropological outlook on the processes linking sociality and ageing.GeroScience · 2025Review
- Using non-invasive behavioral and physiological data to measure biological age in wild baboons.GeroScience · 2024Article
- Epigenetic signatures of social status in wild female spotted hyenas (Crocuta crocuta).Communications biology · 2024Article
- DNA methylation signatures of early-life adversity are exposure-dependent in wild baboons.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Early life adversities and lifelong health outcomes: A review of the literature on large, social, long-lived nonhuman mammals.Neuroscience and biobehavioral reviews · 2023Review
- DNA methylation signatures of early life adversity are exposure-dependent in wild baboons.bioRxiv : the preprint server for biology · 2023Article
- The Experience of BIPOC Living with Chronic Pain in the USA: Biopsychosocial Factors that Underlie Racial Disparities in Pain Outcomes, Comorbidities, Inequities, and Barriers to Treatment.Current pain and headache reports · 2023Review
- Establishment of a co-analysis system for personal identification and body fluid identification: a preliminary report.International journal of legal medicine · 2022Article
- Growing up in a crowd: social environment shapes the offspring's early exploratory phenotype in a colonial breeding species.Royal Society open science · 2022Article
- Article
- Early life adversity has long-term effects on sociality and interaction style in female baboons.Proceedings. Biological sciences · 2022Article
- Early-life social experience affects offspring DNA methylation and later life stress phenotype.Nature communications · 2021Article
Corrections and comments
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Authors and funding
15 authors.
Funding
Abstract
Studies in rodents and captive primates suggest that the early-life social environment affects future phenotype, potentially through alterations to DNA methylation. Little is known of these associations in wild animals. In a wild population of spotted hyenas, we test the hypothesis that maternal care during the first year of life and social connectedness during two periods of early development leads to differences in DNA methylation and fecal glucocorticoid metabolites (fGCMs) later in life. Here we report that although maternal care and social connectedness during the den-dependent life stage are not associated with fGCMs, greater social connectedness during the subadult den-independent life stage is associated with lower adult fGCMs. Additionally, more maternal care and social connectedness after den independence correspond with higher global (%CCGG) DNA methylation. We also note differential DNA methylation near 5 genes involved in inflammation, immune response, and aging that may link maternal care with stress phenotype.
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