ArticleNature communications2021
The tectonigral pathway regulates appetitive locomotion in predatory hunting in mice.
Article in Nature communications, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed, 44 citations in OpenAlex.
- PSD-95 drives binocular vision maturation critical for predation.bioRxiv : the preprint server for biology · 2026Article
- An attention-demanding hunting paradigm engages the superior colliculus-zona incerta circuit mediating analgesia in male mice.Nature communications · 2026Article
- The IC-SNc neural circuit mediates prepulse inhibition deficits in MPTP-induced Parkinson's disease male mice.NPJ Parkinson's disease · 2026Article
- Decreased Oxytocin Mediates PVN-CA2 and PVN-PrL in Sleep Deprivation-Induced Social Memory Deficits.Research (Washington, D.C.) · 2026Article
- Superior Colliculus Projections Drive Dopamine Neuron Activity and Movement But Not Value.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Environmental noise-induced changes to the IC-SNc circuit promotes motor deficits and neuronal vulnerability in a mouse model of Parkinson's Disease.PLoS biology · 2025Article
- Superior colliculus projections drive dopamine neuron activity and movement but not value.bioRxiv : the preprint server for biology · 2025Article
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- Cholecystokinin neurons in the spinal trigeminal nucleus interpolaris regulate mechanically evoked predatory hunting in male mice.Nature communications · 2025Article
- Brainwide Projections of Mouse Dopaminergic Zona Incerta Neurons.The Journal of comparative neurology · 2025Article
- Probabilistically constrained vector summation of motion direction in the mouse superior colliculus.Current biology : CB · 2025Article
- Examining the role of the photopigment melanopsin in the striatal dopamine response to light.Frontiers in systems neuroscience · 2025Article
- Oxytocin modulates inhibitory balance in the prelimbic cortex to support social memory consolidation during REM sleep.Theranostics · 2025Article
- Prefrontal control of superior colliculus modulates innate escape behavior following adversity.Nature communications · 2024Article
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- Sensory Reinforced Corticostriatal Plasticity.Current neuropharmacology · 2024Article
- Collicular circuits supporting the perceptual, motor and cognitive demands of ethological environments.Current opinion in neurobiology · 2023Review
- Neural mechanisms for the localization of unexpected external motion.Nature communications · 2023Article
- Neurocircuitry of Predatory Hunting.Neuroscience bulletin · 2023Review
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Authors and funding
19 authors at 8 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Appetitive locomotion is essential for animals to approach rewards, such as food and prey. The neuronal circuitry controlling appetitive locomotion is unclear. In a goal-directed behavior-predatory hunting, we show an excitatory brain circuit from the superior colliculus (SC) to the substantia nigra pars compacta (SNc) to enhance appetitive locomotion in mice. This tectonigral pathway transmits locomotion-speed signals to dopamine neurons and triggers dopamine release in the dorsal striatum. Synaptic inactivation of this pathway impairs appetitive locomotion but not defensive locomotion. Conversely, activation of this pathway increases the speed and frequency of approach during predatory hunting, an effect that depends on the activities of SNc dopamine neurons. Together, these data reveal that the SC regulates locomotion-speed signals to SNc dopamine neurons to enhance appetitive locomotion in mice.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.