ArticleNature communications2021
A synthetic tubular molecular transport system.
Article in Nature communications, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Nonequilibrium Self-Assembly of Microtubules Through Stepwise Sequential Interactions of DNA.Small (Weinheim an der Bergstrasse, Germany) · 2025Article
- miR-21 Responsive Nanocarrier Targeting Ovarian Cancer Cells.Computational and structural biotechnology journal · 2024Article
- A rhythmically pulsing leaf-spring DNA-origami nanoengine that drives a passive follower.Nature nanotechnology · 2024Article
- Engineering DNA-based cytoskeletons for synthetic cells.Interface focus · 2023Review
- Mechanics of dynamic and deformable DNA nanostructures.Chemical science · 2023Review
- Triple-Stranded DNA As a Structural Element in DNA Origami.ACS nano · 2023Article
- Recent Advances in DNA Origami-Engineered Nanomaterials and Applications.Chemical reviews · 2023Review
- Energy landscapes of rotary DNA origami devices determined by fluorescence particle tracking.Biophysical journal · 2022Article
- DNA-Based Molecular Machines.JACS Au · 2022Review
- Static and Dynamic Gradient Based Directional Transportation of Neutral Molecules in Swollen Polymer Films.Angewandte Chemie (International ed. in English) · 2022Article
- Functional DNA-based cytoskeletons for synthetic cells.Nature chemistry · 2022Article
- Design Features to Accelerate the Higher-Order Assembly of DNA Origami on Membranes.The journal of physical chemistry. B · 2021Article
- A DNA origami-based nanoscale molecular transport railway.Communications biology · 2021Article
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Creating artificial macromolecular transport systems that can support the movement of molecules along defined routes is a key goal of nanotechnology. Here, we report the bottom-up construction of a macromolecular transport system in which molecular pistons diffusively move through micrometer-long, hollow filaments. The pistons can cover micrometer distances in fractions of seconds. We build the system using multi-layer DNA origami and analyze the structures of the components using transmission electron microscopy. We study the motion of the pistons along the tubes using single-molecule fluorescence microscopy and perform Langevin simulations to reveal details of the free energy surface that directs the motions of the pistons. The tubular transport system achieves diffusivities and displacement ranges known from natural molecular motors and realizes mobility improvements over five orders of magnitude compared to previous artificial random walker designs. Electric fields can also be employed to actively pull the pistons along the filaments, thereby realizing a nanoscale electric rail system. Our system presents a platform for artificial motors that move autonomously driven by chemical fuels and for performing nanotribology studies, and it could form a basis for future molecular transportation networks.
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