Evidence map›Paper›PMID 34285142›Full record

ArticleAging2021

An association study in the Taiwan Biobank elicits three novel candidates for cognitive aging in old adults:

Eugene Lin, Po-Hsiu Kuo, Wan-Yu Lin, Yu-Li Liu, Albert C Yang, Shih-Jen Tsai

Open access · hybridAbstract read
In one paragraph

Article in Aging, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.7field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
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  7. Contribution ofPharmacogenomics and personalized medicine · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 6 institutions in 2 countries.

Eugene LinDepartment of Biostatistics, University of Washington, Seattle, WA 98195, USA.
Po-Hsiu KuoDepartment of Public Health, Institute of Epidemiology and Preventive Medicine, National Taiwan University, Taipei 10617, Taiwan.
Wan-Yu LinDepartment of Public Health, Institute of Epidemiology and Preventive Medicine, National Taiwan University, Taipei 10617, Taiwan.
Yu-Li LiuCenter for Neuropsychiatric Research, National Health Research Institutes, Miaoli County 35053, Taiwan.
Albert C YangDivision of Interdisciplinary Medicine and Biotechnology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.
Shih-Jen TsaiDepartment of Psychiatry, Taipei Veterans General Hospital, Taipei 11217, Taiwan.
Beth Israel Deaconess Medical Center · USNational Health Research Institutes · TWNational Taiwan University · TWNational Taiwan University Hospital · TWTaipei Veterans General Hospital · TWUniversity of Washington · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The dopamine receptor-related loci have been suggested to be associated with cognitive functions and neurodegenerative diseases. It is unknown whether genetic variants such as single nucleotide polymorphisms (SNPs) in the dopamine receptor-related loci could contribute to cognitive aging independently as well as by virtue of complicated interplays in the elder population. To assess whether SNPs in the dopamine receptor-related loci are associated with cognitive aging in the elder population, we evaluated SNPs in the

Indexed as

Cognitive AgingPolymorphism, Single NucleotideAgedBiological Specimen BanksCD56 AntigenFemaleGenotypeHumansLinear ModelsMaleMiddle AgedNerve Tissue ProteinsProteinsTaiwanTranscription FactorsCD56 AntigenNCAM1 protein, humanNerve Tissue ProteinsProteinsTranscription FactorsTTC12 protein, humanZBTB20 protein, humanAlzheimer's diseasescognitive agingcognitive impairmentdopamine receptorneurodegeneration

Identifiers

PMID34285142
PMCPMC8351692
OpenAlexW3183847895

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.