ArticleScience translational medicine2021
A recombinant spike protein subunit vaccine confers protective immunity against SARS-CoV-2 infection and transmission in hamsters.
Abstract read
In one paragraph
Article in Science translational medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers.
0numbers the graph read from it
0cells of the map it votes in
51citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
51 citing papers in PubMed.
- Nanobody-based combination vaccine using licensed protein nanoparticles protects animals against respiratory and viral infections.Nature biomedical engineering · 2026Article
- Universal broad-spectrum mucosal vaccine design for human coronaviruses inspired by artificial antibodies.NPJ vaccines · 2026Article
- Spatial transcriptomic mapping of early immune responses to an adjuvanted recombinant hemagglutinin vaccine.Frontiers in immunology · 2026Article
- A novel chimeric coronavirus spike vaccine combining SARS-CoV-2 RBD and scaffold domains from HKU-1 elicits potent neutralising antibody responses.NPJ vaccines · 2025Article
- Article
- Broad neutralizing antibody response of a monomeric spike-based SARS-CoV-2 bivalent vaccine against diverse variants.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Immunogenicity and cellular response of a herpes zoster virus gEgI fusion protein adjuvanted with CpG-emulsion in mice.Journal of nanobiotechnology · 2025Article
- Immunological enhancement of micro-nanoparticle formulated with risedronate and zinc as vaccine adjuvant in aged mice.Immunity & ageing : I & A · 2025Article
- A SARS-CoV-2 vaccine on an NIR-II/SWIR emitting nanoparticle platform.Science advances · 2025Article
- A broad-spectrum SARS-CoV-2 RBD vaccine with selected high-impact mutations and novel adjuvant induces durable T cell response and broad protection in mice.Frontiers in cellular and infection microbiology · 2025Article
- Combination of spatial transcriptomics analysis and retrospective study reveals liver infection of SARS-COV-2 is associated with clinical outcomes of COVID-19.EBioMedicine · 2025Article
- A quadri-fluorescence SARS-CoV-2 pseudovirus system for efficient antigenic characterization of multiple circulating variants.Cell reports methods · 2024Article
- Glycoprotein E-Displaying Nanoparticles Induce Robust Neutralizing Antibodies and T-Cell Response against Varicella Zoster Virus.International journal of molecular sciences · 2024Article
- Mucosal immunization with ChAd-SARS-CoV-2-S prevents sequential transmission of SARS-CoV-2 to unvaccinated hamsters.Science advances · 2024Article
- A cryptic site in class 5 epitope of SARS-CoV-2 RBD maintains highly conservation across natural isolates.iScience · 2024Article
- Article
- The Application of Biomaterials for the Vaccine, Treatment, and Detection of SARS-CoV-2.ACS omega · 2024Review
- Global research on RNA vaccines for COVID-19 from 2019 to 2023: a bibliometric analysis.Frontiers in immunology · 2024Article
- A trimeric spike-based COVID-19 vaccine candidate induces broad neutralization against SARS-CoV-2 variants.Human vaccines & immunotherapeutics · 2023Article
- Durable and enhanced immunity against SARS-CoV-2 elicited by manganese nanoadjuvant formulated subunit vaccine.Signal transduction and targeted therapy · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
36 authors.
Yangtao WuState Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, National Institute of Diagnostics and Vaccine Development in Infectious Diseases, School of Life Sciences & School of Public Health, Xiamen University, Xiamen 361102, P. R. China.ORCID 0000-0002-9429-266X
Xiaofen HuangState Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, National Institute of Diagnostics and Vaccine Development in Infectious Diseases, School of Life Sciences & School of Public Health, Xiamen University, Xiamen 361102, P. R. China.
Lunzhi YuanState Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, National Institute of Diagnostics and Vaccine Development in Infectious Diseases, School of Life Sciences & School of Public Health, Xiamen University, Xiamen 361102, P. R. China.ORCID 0000-0001-7480-0287
Shaojuan WangState Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, National Institute of Diagnostics and Vaccine Development in Infectious Diseases, School of Life Sciences & School of Public Health, Xiamen University, Xiamen 361102, P. R. China.
Yali ZhangState Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, National Institute of Diagnostics and Vaccine Development in Infectious Diseases, School of Life Sciences & School of Public Health, Xiamen University, Xiamen 361102, P. R. China.ORCID 0000-0002-2599-3710
Hualong XiongState Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, National Institute of Diagnostics and Vaccine Development in Infectious Diseases, School of Life Sciences & School of Public Health, Xiamen University, Xiamen 361102, P. R. China.
Rirong ChenState Key Laboratory of Emerging Infectious Diseases, University of Hong Kong, Hong Kong 999077, P. R. China.ORCID 0000-0002-3257-2180
Jian MaState Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, National Institute of Diagnostics and Vaccine Development in Infectious Diseases, School of Life Sciences & School of Public Health, Xiamen University, Xiamen 361102, P. R. China.ORCID 0000-0003-0071-6669
Ruoyao QiState Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, National Institute of Diagnostics and Vaccine Development in Infectious Diseases, School of Life Sciences & School of Public Health, Xiamen University, Xiamen 361102, P. R. China.ORCID 0000-0003-2504-650X
Meifeng NieState Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, National Institute of Diagnostics and Vaccine Development in Infectious Diseases, School of Life Sciences & School of Public Health, Xiamen University, Xiamen 361102, P. R. China.
Jingjing XuState Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, National Institute of Diagnostics and Vaccine Development in Infectious Diseases, School of Life Sciences & School of Public Health, Xiamen University, Xiamen 361102, P. R. China.ORCID 0000-0002-6750-759X
Zhigang ZhangState Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, National Institute of Diagnostics and Vaccine Development in Infectious Diseases, School of Life Sciences & School of Public Health, Xiamen University, Xiamen 361102, P. R. China.ORCID 0000-0001-8830-3628
Liqiang ChenState Key Laboratory of Emerging Infectious Diseases, University of Hong Kong, Hong Kong 999077, P. R. China.ORCID 0000-0002-3712-8636
Min WeiState Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, National Institute of Diagnostics and Vaccine Development in Infectious Diseases, School of Life Sciences & School of Public Health, Xiamen University, Xiamen 361102, P. R. China.ORCID 0000-0001-6812-733X
Ming ZhouState Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, National Institute of Diagnostics and Vaccine Development in Infectious Diseases, School of Life Sciences & School of Public Health, Xiamen University, Xiamen 361102, P. R. China.
Minping CaiState Key Laboratory of Emerging Infectious Diseases, University of Hong Kong, Hong Kong 999077, P. R. China.ORCID 0000-0002-2587-6194
Yang ShiState Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, National Institute of Diagnostics and Vaccine Development in Infectious Diseases, School of Life Sciences & School of Public Health, Xiamen University, Xiamen 361102, P. R. China.ORCID 0000-0003-1247-6084
Liang ZhangState Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, National Institute of Diagnostics and Vaccine Development in Infectious Diseases, School of Life Sciences & School of Public Health, Xiamen University, Xiamen 361102, P. R. China.
Huan YuState Key Laboratory of Emerging Infectious Diseases, University of Hong Kong, Hong Kong 999077, P. R. China.
Junping HongState Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, National Institute of Diagnostics and Vaccine Development in Infectious Diseases, School of Life Sciences & School of Public Health, Xiamen University, Xiamen 361102, P. R. China.
Zikang WangState Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, National Institute of Diagnostics and Vaccine Development in Infectious Diseases, School of Life Sciences & School of Public Health, Xiamen University, Xiamen 361102, P. R. China.
Yunda HongState Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, National Institute of Diagnostics and Vaccine Development in Infectious Diseases, School of Life Sciences & School of Public Health, Xiamen University, Xiamen 361102, P. R. China.ORCID 0000-0003-2948-7652
Mingxi YueState Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, National Institute of Diagnostics and Vaccine Development in Infectious Diseases, School of Life Sciences & School of Public Health, Xiamen University, Xiamen 361102, P. R. China.
Zonglin LiState Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, National Institute of Diagnostics and Vaccine Development in Infectious Diseases, School of Life Sciences & School of Public Health, Xiamen University, Xiamen 361102, P. R. China.
Dabing ChenState Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, National Institute of Diagnostics and Vaccine Development in Infectious Diseases, School of Life Sciences & School of Public Health, Xiamen University, Xiamen 361102, P. R. China.ORCID 0000-0002-5737-2417
Qingbing ZhengState Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, National Institute of Diagnostics and Vaccine Development in Infectious Diseases, School of Life Sciences & School of Public Health, Xiamen University, Xiamen 361102, P. R. China.ORCID 0000-0002-7516-9965
Shaowei LiState Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, National Institute of Diagnostics and Vaccine Development in Infectious Diseases, School of Life Sciences & School of Public Health, Xiamen University, Xiamen 361102, P. R. China.ORCID 0000-0002-3374-1038
Yixin ChenState Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, National Institute of Diagnostics and Vaccine Development in Infectious Diseases, School of Life Sciences & School of Public Health, Xiamen University, Xiamen 361102, P. R. China.ORCID 0000-0002-9591-634X
Tong ChengState Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, National Institute of Diagnostics and Vaccine Development in Infectious Diseases, School of Life Sciences & School of Public Health, Xiamen University, Xiamen 361102, P. R. China.ORCID 0000-0002-1638-6214
Jun ZhangState Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, National Institute of Diagnostics and Vaccine Development in Infectious Diseases, School of Life Sciences & School of Public Health, Xiamen University, Xiamen 361102, P. R. China. zhangj@xmu.edu.cn zhangtianying@xmu.edu.cn zhuhch@hku.hk qinjian_zhao@xmu.edu.cn yuanquan@xmu.edu.cn yguan@hku.hk nsxia@xmu.edu.cn.ORCID 0000-0002-6601-9180
Tianying ZhangState Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, National Institute of Diagnostics and Vaccine Development in Infectious Diseases, School of Life Sciences & School of Public Health, Xiamen University, Xiamen 361102, P. R. China. zhangj@xmu.edu.cn zhangtianying@xmu.edu.cn zhuhch@hku.hk qinjian_zhao@xmu.edu.cn yuanquan@xmu.edu.cn yguan@hku.hk nsxia@xmu.edu.cn.ORCID 0000-0002-2477-329X
Huachen ZhuState Key Laboratory of Emerging Infectious Diseases, University of Hong Kong, Hong Kong 999077, P. R. China. zhangj@xmu.edu.cn zhangtianying@xmu.edu.cn zhuhch@hku.hk qinjian_zhao@xmu.edu.cn yuanquan@xmu.edu.cn yguan@hku.hk nsxia@xmu.edu.cn.ORCID 0000-0003-2711-0501
Qinjian ZhaoState Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, National Institute of Diagnostics and Vaccine Development in Infectious Diseases, School of Life Sciences & School of Public Health, Xiamen University, Xiamen 361102, P. R. China. zhangj@xmu.edu.cn zhangtianying@xmu.edu.cn zhuhch@hku.hk qinjian_zhao@xmu.edu.cn yuanquan@xmu.edu.cn yguan@hku.hk nsxia@xmu.edu.cn.ORCID 0000-0002-6297-9969
Quan YuanState Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, National Institute of Diagnostics and Vaccine Development in Infectious Diseases, School of Life Sciences & School of Public Health, Xiamen University, Xiamen 361102, P. R. China. zhangj@xmu.edu.cn zhangtianying@xmu.edu.cn zhuhch@hku.hk qinjian_zhao@xmu.edu.cn yuanquan@xmu.edu.cn yguan@hku.hk nsxia@xmu.edu.cn.ORCID 0000-0001-5487-561X
Yi GuanState Key Laboratory of Emerging Infectious Diseases, University of Hong Kong, Hong Kong 999077, P. R. China. zhangj@xmu.edu.cn zhangtianying@xmu.edu.cn zhuhch@hku.hk qinjian_zhao@xmu.edu.cn yuanquan@xmu.edu.cn yguan@hku.hk nsxia@xmu.edu.cn.ORCID 0000-0001-6057-9243
Ningshao XiaState Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, National Institute of Diagnostics and Vaccine Development in Infectious Diseases, School of Life Sciences & School of Public Health, Xiamen University, Xiamen 361102, P. R. China. zhangj@xmu.edu.cn zhangtianying@xmu.edu.cn zhuhch@hku.hk qinjian_zhao@xmu.edu.cn yuanquan@xmu.edu.cn yguan@hku.hk nsxia@xmu.edu.cn.ORCID 0000-0003-0179-5266
Funding
No grant is acknowledged in the PubMed record.
Abstract
Multiple safe and effective vaccines that elicit immune responses against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are necessary to respond to the ongoing coronavirus disease 2019 (COVID-19) pandemic. Here, we developed a protein subunit vaccine composed of spike ectodomain protein (StriFK) plus a nitrogen bisphosphonate-modified zinc-aluminum hybrid adjuvant (FH002C). StriFK-FH002C generated substantially higher neutralizing antibody titers in mice, hamsters, and cynomolgus monkeys than those observed in plasma isolated from COVID-19 convalescent individuals. StriFK-FH002C also induced both T
Indexed as
COVID-19AnimalsAntibodies, NeutralizingAntibodies, ViralCOVID-19 VaccinesCricetinaeHumansMiceProtein SubunitsSARS-CoV-2Spike Glycoprotein, CoronavirusAntibodies, NeutralizingAntibodies, ViralCOVID-19 VaccinesProtein SubunitsSpike Glycoprotein, Coronavirus
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.