Evidence map›Paper›PMID 34285121›Full record

ArticleDiabetes2021

T-Cell Expression and Release of Kidney Injury Molecule-1 in Response to Glucose Variations Initiates Kidney Injury in Early Diabetes.

Josephine M Forbes, Domenica A McCarthy, Andrew J Kassianos, Tracey Baskerville, Amelia K Fotheringham, Kurt T K Giuliani, Anca Grivei, Andrew J Murphy, Michelle C Flynn, Mitchell A Sullivan and 20 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Diabetes, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.7field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. Inflammation and Diabetic Kidney Disease.International journal of molecular sciences · 2026
    Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Long-term Visit-to-Visit Variability in Hemoglobin AAmerican journal of kidney diseases : the official journal of the National Kidney Foundation · 2023
    Observational
  9. Article
  10. Review
  11. Article
  12. GWAS of longitudinal trajectories at biobank scale.American journal of human genetics · 2022
    Article
  13. Article
  14. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

30 authors at 9 institutions in 1 country.

Josephine M ForbesMater Research Institute-The University of Queensland, Translational Research Institute, Brisbane, Queensland, Australia josephine.forbes@mater.uq.edu.au.ORCID 0000-0002-5595-8174
Domenica A McCarthyMater Research Institute-The University of Queensland, Translational Research Institute, Brisbane, Queensland, Australia.
Andrew J KassianosFaculty of Medicine, The University of Queensland, St. Lucia, Queensland, Australia.
Tracey BaskervilleMater Research Institute-The University of Queensland, Translational Research Institute, Brisbane, Queensland, Australia.
Amelia K FotheringhamMater Research Institute-The University of Queensland, Translational Research Institute, Brisbane, Queensland, Australia.
Kurt T K GiulianiFaculty of Medicine, The University of Queensland, St. Lucia, Queensland, Australia.
Anca GriveiConjoint Internal Medicine Laboratory, Chemical Pathology, Pathology Queensland, Herston, Queensland, Australia.
Andrew J MurphyHaematopoiesis and Leukocyte Biology, Baker Heart and Diabetes Institute, Melbourne, Victoria, Australia.
Michelle C FlynnHaematopoiesis and Leukocyte Biology, Baker Heart and Diabetes Institute, Melbourne, Victoria, Australia.
Mitchell A SullivanMater Research Institute-The University of Queensland, Translational Research Institute, Brisbane, Queensland, Australia.
Preeti ChandrashekarMater Research Institute-The University of Queensland, Translational Research Institute, Brisbane, Queensland, Australia.
Rani WhiddettMater Research Institute-The University of Queensland, Translational Research Institute, Brisbane, Queensland, Australia.
Kristen J RadfordMater Research Institute-The University of Queensland, Translational Research Institute, Brisbane, Queensland, Australia.
Nicole FlemmingMater Research Institute-The University of Queensland, Translational Research Institute, Brisbane, Queensland, Australia.
Sam S BeardInstitute for Health and Biomedical Innovation, Queensland University of Technology, Translational Research Institute, Brisbane, Queensland, Australia.
Neisha D'SilvaMater Young Adult Health Centre, Mater Misericordiae Ltd, South Brisbane, Queensland, Australia.
Janelle NisbetMater Young Adult Health Centre, Mater Misericordiae Ltd, South Brisbane, Queensland, Australia.
Adam MortonMater Young Adult Health Centre, Mater Misericordiae Ltd, South Brisbane, Queensland, Australia.
Stephanie TeasdaleMater Young Adult Health Centre, Mater Misericordiae Ltd, South Brisbane, Queensland, Australia.
Anthony RussellFaculty of Medicine, The University of Queensland, St. Lucia, Queensland, Australia.ORCID 0000-0003-4902-6693
Nicole IsbelFaculty of Medicine, The University of Queensland, St. Lucia, Queensland, Australia.
Timothy JonesTelethon Kids Institute, Nedlands, Western Australia, Australia.ORCID 0000-0002-7989-1998
Jennifer CouperRobinson Research Institute, University of Adelaide, Adelaide, South Australia, Australia.ORCID 0000-0003-4448-8629
Helen HealyFaculty of Medicine, The University of Queensland, St. Lucia, Queensland, Australia.
Mark HarrisChildren's Health Queensland, South Brisbane, Queensland, Australia.
Kim DonaghueThe Children's Hospital at Westmead and University of Sydney, Sydney, New South Wales, Australia.ORCID 0000-0002-4210-7872
David W JohnsonFaculty of Medicine, The University of Queensland, St. Lucia, Queensland, Australia.
Andrew CotterillChildren's Health Queensland, South Brisbane, Queensland, Australia.
Helen L BarrettMater Research Institute-The University of Queensland, Translational Research Institute, Brisbane, Queensland, Australia.
Trisha O'Moore-SullivanMater Young Adult Health Centre, Mater Misericordiae Ltd, South Brisbane, Queensland, Australia.
Translational Research Institute · AUMater Misericordiae Hospital · AUQueensland Health · AUThe University of Queensland · AUBaker Heart and Diabetes Institute · AUChildren’s Health Queensland Hospital and Health Service · AUThe Kids Research Institute Australia · AUThe University of Adelaide · AUThe University of Sydney · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Half of the mortality in diabetes is seen in individuals <50 years of age and commonly predicted by the early onset of diabetic kidney disease (DKD). In type 1 diabetes, increased urinary albumin-to-creatinine ratio (uACR) during adolescence defines this risk, but the pathological factors responsible remain unknown. We postulated that early in diabetes, glucose variations contribute to kidney injury molecule-1 (KIM-1) release from circulating T cells, elevating uACR and DKD risk. DKD risk was assigned in youth with type 1 diabetes (

Indexed as

AdolescentAdultBlood GlucoseDiabetes Mellitus, Type 1Diabetic NephropathiesFemaleGlomerular Filtration RateHepatitis A Virus Cellular Receptor 1HumansKidneyKidney Function TestsMaleRetrospective StudiesYoung AdultBlood GlucoseHAVCR1 protein, humanHepatitis A Virus Cellular Receptor 1

Identifiers

PMID34285121
PMCPMC8385614
OpenAlexW3137609502

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.