ArticleProceedings of the National Academy of Sciences of the United States of America2021
Active liquid crystals powered by force-sensing DNA-motor clusters.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Motor-driven microtubule diffusion in a photobleached dynamical coordinate system.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Article
- Autonomous assembly and disassembly of gliding molecular robots regulated by a DNA-based molecular controller.Science advances · 2024Article
- Spatio-temporal patterning of extensile active stresses in microtubule-based active fluids.PNAS nexus · 2023Article
- Self-mixing in microtubule-kinesin active fluid from nonuniform to uniform distribution of activity.Nature communications · 2022Article
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Authors and funding
3 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Cytoskeletal active nematics exhibit striking nonequilibrium dynamics that are powered by energy-consuming molecular motors. To gain insight into the structure and mechanics of these materials, we design programmable clusters in which kinesin motors are linked by a double-stranded DNA linker. The efficiency by which DNA-based clusters power active nematics depends on both the stepping dynamics of the kinesin motors and the chemical structure of the polymeric linker. Fluorescence anisotropy measurements reveal that the motor clusters, like filamentous microtubules, exhibit local nematic order. The properties of the DNA linker enable the design of force-sensing clusters. When the load across the linker exceeds a critical threshold, the clusters fall apart, ceasing to generate active stresses and slowing the system dynamics. Fluorescence readout reveals the fraction of bound clusters that generate interfilament sliding. In turn, this yields the average load experienced by the kinesin motors as they step along the microtubules. DNA-motor clusters provide a foundation for understanding the molecular mechanism by which nanoscale molecular motors collectively generate mesoscopic active stresses, which in turn power macroscale nonequilibrium dynamics of active nematics.
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